@article{10902/35408,
year = {2024},
month = {11},
url = {https://hdl.handle.net/10902/35408},
abstract = {With the rationale that the oxidative potential of particulate matter (PM-OP) may induce oxidative stress and inflammation, we conducted the ASTHMA-FENOP study in which 44 asthmatic patients and 37 matched controls wore a personal sampler for 24 h, allowing the collection of fine and coarse PM fractions separately, to determine PM-OP by the dithiothreitol (DTT) and ascorbic acid (AA) methods. The levels of Interleukin 6 (IL-6) and the IL-6/IL-10 ratio, as indicators of pro- and anti-inflammatory statuses, were determined by calculating the mean differences (MDs), odds ratios (ORs) and p-trends adjusted for sex, age, study level and body mass index. Positive associations for IL-6 levels in the form of adjusted MDs and ORs were obtained for all PM-OP metrics, reaching statistical significance for both OP-DTT and OP-AA in the fine fraction, with adjusted OR = 5.66; 95%CI (1.46 to 21.92) and 3.32; 95%CI (1.07 to 10.35), respectively, along with statistically significant dose–response patterns when restricting to asthma and adjusted also for clinical variables (adjusted p-trend = 0.029 and 0.01). Similar or stronger associations and dose–response patterns were found for the IL-6/IL-10 ratio. In conclusion, our findings on the effect of PM-OP on systemic inflammation support that asthma is a heterogeneous disease at the molecular level, with PM-OP potentially playing an important role.},
organization = {This work was supported by the Spanish Society of Pneumology (SEPAR Nº 1383/23; Nº 1616/24) and the Spanish Ministry of Science and Innovation (Project PID2020-114787RBI00, funded by MCIN/AEI/10.13039/501100011033 and “ERDF A way of making Europe”).},
publisher = {MDPI},
publisher = {Antioxidants, 2024, 13(12), 1464},
title = {Association between oxidative potential of particulate matter collected by personal samplers and systemic inflammation among asthmatic and non-asthmatic adults},
author = {Santibáñez Margüello, Miguel and Ruiz Cubillán, Juan José and Expósito Monar, Andrea and Agüero Calvo, Juan and García Rivero, Juan Luis and Abascal Bolado, Beatriz and Amado Diago, Carlos Antonio and Ruiz Azcona, Laura and López Hoyos, Marcos and Irure Ventura, Juan and Robles, Yolanda and Berja Miguel, Ana and Barreiro, Esther and Nuñez Robainas, Adriana and Cifrián Martínez, José Manuel and Fernández Olmo, Ignacio},
}