@article{10902/35226,
year = {2021},
url = {https://hdl.handle.net/10902/35226},
abstract = {Background: Coffee contains many bioactive substances that can play a role on colorectal cancer. Epidemiological evidence of coffee intake and colorectal cancer is, however, inconsistent.
Aim: To provide further information on the risk of colorectal cancer in relation to coffee consumption.
Methods: Data derive from two companion case-control studies conducted in Italy and Spain within the European Union Project on Health Impacts of long-term exposure to disinfection by-products in Drinking Water and the Spanish Multi-Case Control study on Cancer. These included a total of 2289 incident cases with colorectal cancer and 3995 controls with information on coffee intake. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were derived from unconditional logistic regression models, adjusted for study centre, sex, age, education, smoking, and other covariates.
Results: Compared with never coffee drinkers, the OR was 0.99 (95% CI 0.95-1.02) for total coffee consumption. There was no significant trend in risk with dose or duration, the ORs being 0.95 (95% CI 0.72-1.25) for an amount of five or more cups per day of coffee and 0.95 (95% CI 0.75-1.19) for a duration of consumption of 50 years or longer. The OR was 1.04 (95% CI 0.87-1.25) for two or more cups per day of decaffeinated coffee. There were no heterogeneity across strata of various covariates, as well as no apparent differences between various anatomical subsites.
Conclusion: This large pooled analysis of two studies shows no association of coffee and decaffeinated coffee with colorectal cancer risk.},
publisher = {Lippincott, Williams & Wilkins},
publisher = {European Journal of Cancer Prevention, 2021 May 1;30(3):204-210.},
title = {Coffee consumption and colorectal cancer risk: a multicentre case-control study from Italy and Spain},
author = {Rosato, Valentina and Guercio, Valentina and Bosetti, Cristina and Gracia-Lavedan, Esther and Villanueva, Cristina M. and Polesel, Jerry and Toffoluti, Federica and Moreno, Victor and Martin, Vicente and Aragonés, Nuria and Dierssen Sotos, Trinidad and Olmedo-Requena, Rocío and Guevara, Marcela and Amiano, Pilar and Salas, Dolores and Fernandez-Tardon, Guillermo and Alguacil, Juan and Chirlaque López, María Dolores and Fernandez-Villa, Tania and Pérez-Gómez, Beatriz and Gómez Acebo, Inés and Jiménez-Moleón, Jose J. and Moreno-Iribas, Conchi and José Molina, Antonio and Castaño Vinyals, Gemma and Pollan, Marina and Kogevinas, Manolis and La Vecchia, Carlo and Tavani, Alessandra},
}