@article{10902/35159,
year = {2024},
url = {https://hdl.handle.net/10902/35159},
abstract = {Eukaryotic cells must accurately transfer their genetic material and cellular components to their daughter cells. Initially, cells duplicate their chromosomes and subsequently segregate them toward the poles. The actomyosin ring, a crucial molecular machinery normally located in the middle of the cells and underneath the plasma membrane, then physically divides the cytoplasm and all components into two daughter cells, each ready to start a new cell cycle. This process, known as cytokinesis, is conserved throughout evolution. Defects in cytokinesis can lead to the generation of genetically unstable tetraploid cells, potentially initiating uncontrolled proliferation and cancer. This review focuses on the molecular mechanisms by which budding yeast cells build the actomyosin ring and the preceding steps involved in forming a scaffolding structure that supports the challenging structural changes throughout cytokinesis. Additionally, we describe how cells coordinate actomyosin ring contraction, plasma membrane ingression, and extracellular matrix deposition to successfully complete cytokinesis. Furthermore, the review discusses the regulatory roles of Cyclin-Dependent Kinase (Cdk1) and the Mitotic Exit Network (MEN) in ensuring the precise timing and execution of cytokinesis. Understanding these processes in yeast provides insights into the fundamental aspects of cell division and its implications for human health.},
organization = {This research was funded by Agencia Estatal de Investigación (AEI) of Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033) under grant numbers PID2019-106745GB-I00 and PID2023-150648NB-I00. In addition, it was supported by a grant from the Consejería de Universidades, Investigación, Medio Ambiente y Política Social del Gobierno de Cantabria and another grant from Sociedad para el Desarrollo de Cantabria (SODERCAN). The authors would like to thank the anonymous reviewers for their constructive comments, which helped to improve this review.},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
publisher = {Journal of Fungi, 2024,
10, 662},
title = {Central role of the actomyosin ring in coordinating cytokinesis steps in budding yeast},
author = {Foltman, Magdalena and Sánchez Díaz, Alberto},
}