@article{10902/34545,
year = {2024},
url = {https://hdl.handle.net/10902/34545},
abstract = {Background: Klebsiella aerogenes has been reclassified from Enterobacter to Klebsiella genus due to its phenotypic and genotypic similarities with Klebsiella pneumoniae. It is unclear if clinical outcomes are also more similar. This study aims to assess clinical outcomes of bloodstreams infections (BSI) caused by K. aerogenes, K. pneumoniae and Enterobacter cloacae, through secondary data analysis, nested in PRO-BAC cohort study. Methods: Hospitalized patients between October 2016 and March 2017 with monomicrobial BSI due to K. aerogenes, K. pneumoniae or E. cloacae were included. Primary outcome was a composite clinical outcome including all-cause mortality or recurrence until 30 days follow-up. Secondary outcomes were fever ≥72 h, persistent bacteraemia, and secondary device infection. Multilevel mixed-effect Poisson regression was used to estimate the association between microorganisms and outcome. Results: Overall, 29 K. aerogenes, 77 E. cloacae and 337 K. pneumoniae BSI episodes were included. Mortality or recurrence was less frequent in K. aerogenes (6.9%) than in E. cloacae (20.8%) or K. pneumoniae (19.0%), but statistical difference was not observed (rate ratio (RR) 0.35, 95% CI 0.08 to 1.55; RR 0.42, 95% CI 0.10 to 1.71, respectively). Fever ≥72 h and device infection were more common in K. aerogenes group. In the multivariate analysis, adjusted for confounders (age, sex, BSI source, hospital ward, Charlson score and active antibiotic therapy), the estimates and direction of effect were similar to crude results. Conclusions: Results suggest that BSI caused by K. aerogenes may have a better prognosis than E. cloacae or K. pneumoniae BSI.},
organization = {Funding: the PROBAC project was fnanced by grants from Plan Nacional de I+D+i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades [PI16/01432] and the Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0008], cofnanced by the European Development Regional Fund ‘A way to achieve Europe’, Operative program Intelligent Growth 2014–2020. Acknowledgements: PROBAC/GEIRASSEIMC/SAMAMICEI project: Eva Leon (HU Virgen de Valme), Inés Pérez Camacho (Hospital General de Poniente), David Vinuesa García (HU Clínico San Cecilio), Jordi Cuquet Pedragosa (HU Granollers), Isabel María Reche Molina (HU Torrecárdenas), Alberto BahamondeCarrasco (Hospital de El Bierzo), Carmen Herrero Rodríguez (Complejo Hospitalario de Jaén), Marcos Barcelona, Spain. 9 Unidad de Enfermedades Infecciosas y Microbiologia Clinica, Hospital Universitario Jerez De La Frontera, Jerez De La Frontera, Cádiz, Spain. 10 Servicio de Enfermedades Infecciosas, Hospital Universitario Marqués de ValdecillaIDIVAL, Universidad de Cantabria, Santander, Spain. 11Unidad de Gestión Clínica de Microbiología, Hospital Universitario Puerta del Mar, Cádiz, Spain. 12Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sofa, Cordoba, Spain. 13Unidad de Infección Nosocomial, Hospital Universitario Arnau de Vilanova, Lleida, Spain. 14Unidad de EnfermedadesInfecciosas, Hospital Universitario de Cruces, Barakaldo, Spain. 15Unidad deGestión Clínica de Enfermedades Infecciosas, Hospital Universitario de Burgos, Burgos, Spain. 16Departamento de Microbiología Clínica, Complejo Asistencial Universitario de León (CAULE), León, Spain. 17Grupo Enfermedades Infecciosas,Servicio de Medicina Interna, Hospital Costa del Sol, Marbella, Spain. 18Unidad de Microbiología, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain.},
publisher = {BMC},
publisher = {Annals of Clinical Microbiology and Antimicrobials, 2024, 23(1), 42},
title = {Differences in clinical outcomes of bloodstream infections caused by Klebsiella aerogenes, Klebsiella pneumoniae and Enterobacter cloacae: a multicentre cohort study},
author = {Guedes, M. and Gathara, D. and López-Hernández, I. and Martínez Pérez Crespo, P. M. and Pérez Rodríguez, M. T. and Sousa, A. and Plata, A. and Reguera Iglesias, J. M. and Boix Palop, L. and Dietl, B. and Blanco, J.S. and Armiñanzas Castillo, Carlos and Galán Sánchez, F. and Kindelán, C.N. and Jover Saenz, A. and Aguirre, J.G. and Alemán Alemán, Ana and Marrodán Ciordia, Teresa and Del Arco Jiménez, Alfonso},
}