@article{10902/34510,
year = {2024},
month = {11},
url = {https://hdl.handle.net/10902/34510},
abstract = {The alarming rise in chronic diseases worldwide highlights the urgent need to overcome the limitations of conventional drug delivery systems. In this context, osmotic pumps are able to release drugs by differential osmotic pressure, achieving a controlled rate independent of physiological factors and reducing the dosing frequency. As osmotic pumps are based on the phenomenon of osmosis, the choice of high osmolality draw solutions (DSs) is a critical factor in the successful delivery of the target drug. Therefore, one alternative that has received particular attention is the formulation of DSs with magnetic nanoparticles (MNPs) due to their easy recovery, negligible reverse solute flux (RSF), and their possible tailor-made functionalization to generate high osmotic gradients. In this work, the possible integration of DSs formulated with MNPs in controlled drug delivery systems is discussed for the first time. In particular, the main potential advantages that these novel medical devices could offer, including improved scalability, regeneration, reliability, and enhanced drug delivery performance, are provided and discussed. Thus, the results of this review may demonstrate the potential of MNPs as osmotic agents, which could be useful for advancing the design of osmotic pump-based drug delivery systems.},
organization = {This research was developed in the framework of the projects PID2020-115409RB-I00 financed by MICIU/AEI/10.13039/501100011033 and PDC2021-120786-I00 and TED2021-129874B-I00 financed by MICIU/AEI/10.13039/501100011033 and by the European Union Next Generation EU/PRTR. David Navarro-Tumar is grateful for the Concepción Arenal predoctoral contract UC-23-28 from the University of Cantabria. Belén García-Merino would also like to express her gratitude to the Spanish Ministry of Science, Innovation, and Universities for the FPI predoctoral grant PRE2019-089339 funded by MICIU/AEI/10.13039/501100011033 and by “ESF Investing in your future”. Cristina González-Fernández also thanks the Spanish Ministry of Universities for the Margarita Salas postdoctoral fellowship (grants for the requalification of the Spanish university system for 2021–2023, University of Cantabria), funded by the European Union–NextGenerationEU.},
publisher = {MDPI},
publisher = {Sensors, 2024, 24(21), 7042},
title = {Novel applications in controlled drug delivery systems by integrating osmotic pumps and magnetic nanoparticles},
author = {Navarro Tumar, David and García Merino, Belén and González Fernández, Cristina and Ortiz Uribe, Inmaculada and San Román San Emeterio, María Fresnedo and Bringas Elizalde, Eugenio},
}