@article{10902/34451,
year = {2024},
url = {https://hdl.handle.net/10902/34451},
abstract = {Abstract: In patients with chronic kidney disease (CKD), the main cause of morbidity and mortality is cardiovascular disease (CVD). Both coronary artery calcium scoring by computed tomography (CT) and optical coherence tomography (OCT) are used to identify patients at increased risk for ischemic heart disease, thereby indicating a higher cardiovascular risk profile. Our study aimed to investigate the utility of these techniques in the CKD population. In patients with CKD, OCT was used to measure the choroidal thickness (CHT) and the thickness of the peripapillary retinal nerve fiber layer (pRNFL). A total of 127 patients were included, including 70 men (55%) with an estimated glomerular filtration rate (eGFR) of 39 ± 30 mL/min/1.73 m2 . Lower pRNFL thickness was found to be related to high-sensitivity troponin I (r=-0.362, p < 0.001) and total coronary calcification (r=-0.194, p=0.032). In a multivariate analysis, pRNFL measurements remained asso ciated with age (β = -0.189; -0.739--0.027; p=0.035) and high-sensitivity troponin I (β = -0.301; -0.259--0.071; p < 0.001). Severe coronary calcification (Agatston score ≥ 400 HU) was related to a worse eGFR (p = 0.008), a higher grade of CKD (p = 0.036), and a thinner pRNFL (p = 0.011). The ROC curve confirmed that the pRNFL measurement could determine the patients with an Agatston score of ≥400 HU (AUC 0.638; 95% CI 0.525-0.750; p = 0.015). Our study concludes that measurement of pRNFL thickness using OCT is related to the markers associated with ischemic heart disease, such as coronary calcification and high-sensitivity troponin I, in the CKD population.},
organization = {Funding: This research was funded by the Marqués de Valdecilla University Hospital—IDIVAL research institute with TRANSVAL 18/01, NextVal 18/09, MTVAL 18/01 and RICORS2040 (RD21/0005/0010). Acknowledgments: We would like to thank our nursing team in the Nephrology Laboratory Rosa Ana Sainz Alonso and our research laboratory technician María Consuelo Agüeros Blanco for their help when collecting blood samples.},
publisher = {MDPI},
publisher = {Life (Basel, Switzerland), 2024,14(4), 533},
title = {Looking into the eyes to see the heart of chronic kidney disease patients},
author = {Kislikova, Maria and Gaitán Valdizán, Jorge Javier and Parra Blanco, J.A. and García Unzueta, María Teresa and Rodríguez Vidriales, M. and Escagedo Cagigas, Clara and Piñera Haces, V. C. and Valentín Muñoz, M. O. and Benito Hernández, A. and Ruiz San Millán, Juan Carlos and Rodrigo Calabia, Emilio},
}