@article{10902/34415,
year = {2012},
month = {3},
url = {https://hdl.handle.net/10902/34415},
abstract = {Antimicrobial peptides constitute an important factor inthe defense of plants against pathogens, and bacterial resis-tance to these peptides have previously been shown to bean important virulence factor in Dickeya dadantii, thecausal agent of soft-rot disease of vegetables. In order tounderstand the bacterial response to antimicrobial pep-tides, a transcriptional microarray analysis was performedupon treatment with sub-lethal concentration of thionins, awidespread plant peptide. In all, 36 genes were found to beoverexpressed, and were classified according to their de-duced function as i) transcriptional regulators, ii) trans-port, and iii) modification of the bacterial membrane. Onegene encoding a uricase was found to be repressed. Themajority of these genes are known to be under the controlof the PhoP/PhoQ system. Five genes representing the dif-ferent functions induced were selected for further analysis.The results obtained indicate that the presence of antimi-crobial peptides induces a complex response which includespeptide-specific elements and general stress-response ele-ments contributing differentially to the virulence in differ-ent hosts.},
organization = {This research has been supported by the Spanish Plan Nacional I+D+Igrant AGL-2009-12757. J. J. Rodríguez-Herva is funded by the program“Ramón y Cajal” from the Spanish Ministry of Science and Innovation(RYC-2007-01045). I. Rio-Alvarez is supported by the FPI program(MICINN-Spain). We acknowledge G. Garcia Casado (Centro Nacional deBiotecnología, CSIC, Madrid) for assistance with microarray data analysis},
publisher = {APS Press},
publisher = {Molecular plant-microbe interactions : MPMI, 2012, 25(4), 443-598},
title = {Genome-wide analysis of the response of Dickeya dadantii 3937 to plant antimicrobial peptides.},
author = {Río Álvarez, Isabel and Rodríguez Herva, José J. and Cuartas Lanza, Raquel and Toth, Ian and Pritchard, Leighton and Rodríguez Palenzuela, Pablo and López Solanilla, Emilia},
}