@article{10902/33547,
year = {2024},
url = {https://hdl.handle.net/10902/33547},
abstract = {Background: Video-oculography constitutes a highly-sensitive method of characterizing ocular movements, which could detect subtle premotor changes and contribute to the early diagnosis of Parkinson's disease (PD). Objective: To investigate potential oculomotor differences between idiopathic PD (iPD) and PD associated with the G2019S variant of LRRK2 (L2PD), as well as to evaluate oculomotor function in asymptomatic carriers of the G2019S variant of LRRK2. Methods: The study enrolled 129 subjects: 30 PD (16 iPD, 14 L2PD), 23 asymptomatic carriers, 13 non-carrier relatives of L2PD patients, and 63 unrelated HCs. The video-oculographic evaluation included fixation, prosaccade, antisaccade, and memory saccade tests. Results: We did not find significant differences between iPD and L2PD. Compared to controls, PD patients displayed widespread oculomotor deficits including larger microsaccades, hypometric vertical prosaccades, increased latencies in all tests, and lower percentages of successful antisaccades and memory saccades. Non-carrier relatives showed oculomotor changes with parkinsonian features, such as fixation instability and hypometric vertical saccades. Asymptomatic carriers shared multiple similarities with PD, including signs of unstable fixation and hypometric vertical prosaccades; however, they were able to reach percentages of successful antisaccade and memory saccades similar to controls, although at the expense of longer latencies. Classification accuracy of significant oculomotor parameters to differentiate asymptomatic carriers from HCs ranged from 0.68 to 0.74, with BCEA, a marker of global fixation instability, being the parameter with the greatest classification accuracy. Conclusions: iPD and LRRK2-G2019S PD patients do not seem to display a differential oculomotor profile. Several oculomotor changes in asymptomatic carriers of LRRK2 mutations could be considered premotor biomarkers.},
publisher = {IOS Press},
publisher = {Journal of Parkinson's Disease, 2024, 14, 797-808},
title = {Oculomotor dysfunction in idiopathic and LRRK2-parkinson's disease and at-risk individuals},
author = {Lage Martínez, Carmen and Sánchez-Rodríguez, Antonio and Rivera-Sánchez, María and Sierra Peña, María and González Aramburu, Isabel and Madera Fernández, Jorge and Delgado Alvarado, Manuel and López García, Sara and Martínez Dubarbie, Francisco and Fernández Matarrubia, Marta and Martínez-Amador, Néstor and Martínez Rodríguez, Mª Isabel and Calvo-Córdoba, Alberto and Rodríguez Rodríguez, Eloy Manuel and García-Cena, Cecilia and Sánchez-Juan, Pascual and Infante Ceberio, Jon},
}