@phdthesis{10902/33133,
year = {2024},
month = {6},
url = {https://hdl.handle.net/10902/33133},
abstract = {En los últimos años, ha habido un interés creciente en el uso de nanopartículas, debido a su reducido tamaño, alta relación volumen/superficie y capacidad de funcionalización. Sin embargo, los inconvenientes de los métodos de síntesis convencionales y la falta de procesos estandarizados para la evaluación de su comportamiento, remarcan la necesidad de desarrollar nuevas alternativas. Por ello, el objetivo de esta tesis es avanzar en el desarrollo de metodologías controladas, rápidas y fiables, para la síntesis y evaluación del rendimiento de nanopartículas funcionalizadas con posibles aplicaciones medioambientales y biomédicas. En concreto, en este trabajo se aborda: i) la producción altamente controlada de nanopartículas magnéticas funcionalizadas con grupos amino, seguida de la evaluación de su eficacia para la captura de contaminantes acuosos; ii) la síntesis de nanopartículas de sílice mesoporosas funcionalizadas con grupos amino, y la evaluación continua de su potencial como nanoportadores para el transporte de fármacos.},
abstract = {In the past few years, there has been a growing interest in the use of nanoparticles, due to their small size, high volume/surface ratio and capacity to functionalize. Nevertheless, the drawbacks of conventional synthesis methods and the lack of standardized procedures for the evaluation of their behavior, remark the need to develop novel alternatives. Therefore, the aim of this thesis is to advance in the development of highly controlled, fast and reliable methodologies for the synthesis and screening of functionalized nanoparticles with potential applications in the environmental and biomedical fields. Specifically, this work addresses: i) the controlled production of amino-functionalized magnetic nanoparticles, followed by the evaluation of their effectiveness in the capture of aqueous pollutants; ii) the synthesis of amino functionalized mesoporous silica nanoparticles, and the continuous screening of their performance as nanocarriers in drug delivery.},
organization = {The research was financially supported by the Spanish Ministry of Science, Innovation and Universities through the projects RTI2018-093310-B-I00 (MINECO/FEDER,UE) “High performance microfluidic separations. Challenges and opportunities” and PDC2022-133122-I00 “Microfluidic platform for efficient selection of environmental remediation technologies”, as well as the FPI predoctoral grant PRE2019–089339.
As part of the requirements for obtaining the International Doctorate mention, an international research stay was completed at the Centre for Biomedicine of the University of Hull (Hull, England), during the period May - August 2023, under the supervision of Dr. Pedro Beltran-Alvarez. This mobility was supported by the afore mentioned FPI predoctoral grant and the project Erasmus+ nº 2021-1-ES01-KA131-HED-000005117.},
title = {Avances en el diseño y síntesis de nanopartículas funcionalizadas para aplicaciones medioambientales y biomédicas},
author = {García Merino, Belén},
}