@article{10902/33037,
year = {2014},
url = {https://hdl.handle.net/10902/33037},
abstract = {Objective: The association between obstructive sleep apnea (OSA) and cancer mortality has scarcely been studied. The objective of this study was to investigate whether OSA is associated with increased cancer mortality in a large cohort of patients with OSA suspicion. Methods: This was a multicenter study in consecutive patients investigated for suspected OSA. OSA severity was measured by the apnea-hypopnea index (AHI) and the hypoxemia index (% night-time spent with oxygen saturation <90%, TSat₉₀). The association between OSA severity and cancer mortality was assessed using Cox's proportional regression analyses after adjusting for relevant confounders. Results: In all, 5427 patients with median follow-up of 4.5 years were included. Of these, 527 (9.7%) were diagnosed with cancer. Log-transformed TSat₉₀ was independently associated with increased cancer mortality in the entire cohort (hazard ratio [HR], 1.21; 95% confidence interval [CI], 1.03-1.42), as well as in the group of patients with cancer (HR, 1.19; 95% CI, 1.02-1.41). The closest association was shown in patients <65years in both the AHI (continuous log-transformed AHI: HR, 1.87; 95% CI, 1.1-3.2; upper vs lower AHI tertile: HR, 3.98; 95% CI, 1.14-3.64) and the TSat₉₀ (continuous log-transformed TSat₉₀: HR, 1.73; 95% CI, 1.23-2.4; upper vs. lower TSat₉₀ tertile: HR, 14.4; 95% CI, 1.85-111.6). Conclusions: OSA severity was associated with increased cancer mortality, particularly in patients aged <65 years.},
organization = {Funding source: (058/2011) Spanish Respiratory Society (SEPAR).},
publisher = {Elsevier},
publisher = {Sleep Medicine, 2014, 15(7), 742-748},
title = {Obstructive sleep apnea is associated with cancer mortality in younger patients},
author = {Martínez García, Miguel A. and Campos Rodriguez, Francisco and Durán Cantolla, Joaquín and Peña, Mónica de la and Masdeu, María J. and González Martínez, Mónica and Campo, Félix del and Catalán Serra, Pablo and Valero Sánchez, Irene and Selma Ferrer, M. J. and Marín, José M. and Barbé, Ferrán and Martínez, M. and Farré, Ramón and Montserrat, José M.},
}