@article{10902/32912,
year = {2016},
month = {2},
url = {https://hdl.handle.net/10902/32912},
abstract = {Multimodal nanoparticulate materials are described, offering magnetic, radionuclide, and fluorescent imaging capabilities to exploit the complementary advantages of magnetic
resonance imaging (MRI), positron emission tomography/singlephoton emission commuted tomography (PET/SPECT), and optical imaging. They comprise Fe₃O₄@NaYF₄ core/shell
nanoparticles (NPs) with different cation dopants in the shell or core, including Co₀.₁₆Fe₂.₈₄O₄@NaYF₄(Yb, Er) and Fe₃O₄@NaYF₄(Yb, Tm). These NPs are stabilized by bisphosphonate polyethylene glycol conjugates (BP-PEG), and then show a high transverse relaxivity (r₂) up to 326 mM−¹ s−¹ at 3T, a high affinity to [¹⁸F]-fluoride or radiometal-bisphosphonate conjugates (e.g., ⁶⁴Cu and ⁹⁹mTc), and fluorescent emissions from 500 to 800 nm under excitation at 980 nm. The biodistribution of intravenously administered particles determined by PET/MR imaging suggests that negatively charged Co₀.₁₆Fe₂.₈₄O₄@NaYF₄(Yb, Er)-BP-PEG (10K) NPs cleared from the blood pool more slowly
than positively charged NPs Fe₃O₄@NaYF₄(Yb, Tm)-BP-PEG (2K). Preliminary results in sentinel lymph node imaging in mice indicate the advantages of multimodal imaging.},
organization = {This research was supported by the Centre of Excellence in Medical Engineering Centre funded by the Wellcome Trust and EPSRC under grant number WT088641/Z/09/Z, and the King’s College London and UCL Comprehensive Cancer Imaging Centre funded by CRUK and EPSRC in association with the MRC and DoH (England), and by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. PET and SPECT scanning equipment was funded by an equipment grant from the Wellcome Trust. IH thanks EU FP7 for Marie Curie CIG 303535. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.},
publisher = {American Chemical Society},
publisher = {Bioconjugate Chemistry, 2016, 27(2), 319-328},
title = {Synthesis, characterization, and application of core-shell Co₀.₁₆Fe₂.₈₄O₄@NaYF₄(Yb, Er) and Fe₃O₄@NaYF₄(Yb, Tm) nanoparticle as trimodal (MRI, PET/SPECT, and optical) imaging agents},
author = {Cui, Xianjin and Mathe, Domokos and Kovács, Noémi and Horváth, Ildikó and Jauregui-Osoro, Maite and Torres Martin De Rosales, Rafael and Mullen, Gregory E. D. and Wong, Wilson and Yan, Yong and Krüger, Dirk and Khlobystov, Andrei N. and Gimenez-Lopez, Maria and Semjeni, Mariann and Szigeti, Krisztián and Veres, Dániel S. and Lu, Haizhou and Hernández Campo, Ignacio and Gillin, William P. and Protti, Andrea and Petik, Katalin Kis},
}