@article{10902/32759,
year = {2022},
url = {https://hdl.handle.net/10902/32759},
abstract = {We mathematically justify metronomic chemotherapy as the best strategy to apply many cytotoxic drugs in oncology for both curative and palliative approaches, assuming the classical pharmacokinetic model together with the Emax pharmacodynamic and the Norton-Simon hypothesis. From the mathematical point of view, we will consider two mixed-integer nonlinear optimization problems, where the unknowns are the number of the doses and the quantity of each one, adjusting the administration times a posteriori.},
organization = {We thank the reviewers for their comments, which have contributed to improving the work. The first and second authors were supported by MCIN/ AEI/10.13039/501100011033/ under research projects MTM2017-83185-P
and PID2020-114837GB-I00.},
publisher = {EDP Sciences},
publisher = {Mathematical Modelling of Natural Phenomena, 2022, 17, 2022010},
title = {A mathematical justification for metronomic chemotherapy in oncology},
author = {Fernández Fernández, Luis Alberto and Pola Méndez, Cecilia and Sáinz-Pardo Díaz, Judith},
}