@article{10902/32687,
year = {2018},
url = {https://hdl.handle.net/10902/32687},
abstract = {T cells compete with malignant cells for limited nutrients within the solid tumor microenvironment. We found that effector memory CD4 T cells respond distinctly from other T cell subsets to limiting glucose and can maintain high levels of interferon-γ (IFN-γ) production in a nutrient-poor environment. Unlike naive (TN) or central memory T (TCM) cells, effector memory T (TEM) cells fail to upregulate fatty acid synthesis, oxidative phosphorylation, and reductive glutaminolysis in limiting glucose. Interference of fatty acid synthesis in naive T cells dramatically upregulates IFN-γ, while increasing exogenous lipids in media inhibits production of IFN-γ by all subsets, suggesting that relative ratio of fatty acid metabolism to glycolysis is a direct predictor of T cell effector activity. Together, these data suggest that effector memory T cells are programmed to have limited ability to synthesize and metabolize fatty acids, which allows them to maintain T cell function in nutrient-depleted microenvironments. Ecker et al. distinguish unique metabolic and functional properties of naive and memory T cell subsets during glucose limitation. During glucose starvation, T cells begin to differentially rely on fatty acid synthesis and glutamine utilization to survive. Unexpectedly, reliance on fatty acid synthesis alters the ability to produce IFN-γ.},
publisher = {Cell Press Elsevier},
publisher = {Cell Reports, 2018, 23(3), 741-755},
title = {Differential reliance on lipid metabolism as a salvage pathway underlies functional differences of T cell subsets in poor nutrient environments},
author = {Ecker, Christopher and Guo, Lili and Voicu, Stefana and Gil de Gómez Sesma, Luis and Medvec, Andrew and Cortina, Luis and Pajda, Jackie and Andolina, Melanie and Torres-Castillo, Maria and Donato, Jennifer L. and Mansour, Sarya and Zynda, Evan R. and Lin, Pei-Yi and Varela-Rohena, Angel and Blair, Ian A. and Riley, James L.},
}