@article{10902/32665,
year = {2023},
url = {https://hdl.handle.net/10902/32665},
abstract = {Eosinophil-related diseases represent a group of pathologic conditions with highly heterogeneous clinical presentation and symptoms ranging from mild to critical. Both systemic and localized forms of disease are typically treated with glucocorticoids. The approval of novel biologic therapies targeting the interleukin-5 pathway can help reduce the use of systemic glucocorticoids (SGC) in eosinophilic diseases and reduce the risk of SGC-related adverse effects (AEs). In this article, a panel of experts from different medical specialties reviewed current evidence on the use of SGC in two systemic eosinophilic diseases: Eosinophilic Granulomatosis with PolyAngiitis (EGPA) and HyperEosinophilic Syndrome (HES); and in two single-organ (respiratory) eosinophilic diseases: Chronic RhinoSinusitis with Nasal Polyps (CRSwNP) and Severe Asthma with Eosinophil Phenotype (SA-EP), and contrasted it with their experience in clinical practice. Using nominal group technique, they reached consensus on key aspects related to the dose and tapering of SGC as well as on the initiation of biologics as SGC-sparing agents. Early treatment with biologics could help prevent AEs associated with medium and long-term use of SGC.},
organization = {Funding: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The author(s) declare that GSK funded the medical writing support for this manuscript. 
Acknowledgments: We would like to thank Mónica Hoyos (medical writer) on behalf of Springer Healthcare Communications. This medical writing assistance was funded by GSK and facilitated by Springer Healthcare.},
publisher = {Frontiers Research Foundation},
publisher = {Frontiers in Immunology, 2024, 14, 1310211},
title = {Expert consensus on the use of systemic glucocorticoids for managing eosinophil-related diseases},
author = {Pozo, Victoria del and Bobolea, Irina and Rial, Manuel J. and Espigol-Frigolé, Georgina and Solans Laqué, Roser and Hernández-Rivas, Jesús María and Mora, Elvira and Crespo-Lessmann, Astrid and Izquierdo Alonso, José Luis and Domínguez Sosa, María Sandra and Maza-Solano, Juan and Atienza Mateo, Belén  and Bañas-Conejero, David and Moure, Abraham L. and Rúa-Figueroa, Íñigo},
}