@article{10902/31738,
year = {2023},
url = {https://hdl.handle.net/10902/31738},
abstract = {Introduction/objectives: DISH has traditionally been considered a non-inflammatory rheumatic disorder. Currently, an inflammatory component has been theorized in the early phases of this condition (EDISH). The study is aimed at investigating a possible relationship between EDISH and chronic inflammation. Method: Analytical-observational study: participants from the Camargo Cohort Study were enrolled. We collected clinical, radiological, and laboratory data. C-reactive protein (CRP), albumin-to-globulin ratio (AGR), and triglyceride-glucose (TyG) index were assessed. EDISH was defined by Schlapbach's scale grades I or II. A fuzzy matching with tolerance factor = 0.2 was performed. Subjects without ossification (NDISH), sex- and age-matched with cases (1:4), acted as controls. Definite DISH was an exclusion criterion. Multivariable analyses were performed. Results: We evaluated 987 persons (mean age 64 ± 8 years; 191 cases with 63.9% women). EDISH subjects presented more frequently obesity, T2DM, MetS, and the lipid pattern [↑TG ↓TC]. TyG index and alkaline phosphatase (ALP) were higher. Trabecular bone score (TBS) was significantly lower (1.310 [0.2] vs. 1.342 [0.1];  =0.025). CRP and ALP showed the highest correlation (r=0.510; p=0.0001) at lowest TBS level. AGR was lower, and its correlations with ALP (r=-0.219; p=0.0001) and CTX (r=- 0.153; p= 0.022), were weaker or non-significant in NDISH. After adjustment for potential confounders, estimated CRP means for EDISH and NDISH were 0.52 (95% CI: 0.43-0.62) and 0.41 (95% CI: 0.36-0.46), respectively (p=0.038). Conclusions: EDISH was associated with chronic inflammation. Findings revealed an interplay between inflammation, trabecular impairment, and the onset of ossification. Lipid alterations were similar to those observed in chronic-inflammatory diseases},
organization = {This work was supported by a grant from Instituto de Salud Carlos III (PI21/00532) that could be co-funded by European Union FEDER funds.},
publisher = {Springer},
publisher = {Clinical Rheumatology, 2023, 42(7), 1931-1941},
title = {Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study},
author = {Pariente Rodrigo, Emilio Jesús and Pini, Stefanie F. and Olmos Martínez, José Manuel and Fierro, Patricia and Landeras, Rosa and Ramos Barrón, María del Carmen and Martínez Taboada, Víctor Manuel and Hernández Hernández, José Luis},
}