@article{10902/31709,
year = {2023},
url = {https://hdl.handle.net/10902/31709},
abstract = {Objective: To assess the spectrum of PET-CT-related large vessel vasculitis (LVV) in a Spanish tertiary center and to determine whether FDG uptake by PET-CT differs between giant cell arteritis (GCA) with predominant cranial or extracranial phenotypes. 
Methods: The spectrum of patients diagnosed with LVV by PET-CT in a tertiary referral hospital that cares for 450,000 people over a period of two years was reviewed. Moreover, differences in FDG uptake between LVV-GCA with predominantly cranial and extracranial phenotype were analyzed. 
Results: Eighty patients were diagnosed with LVV by PET-CT. Most were due to systemic vasculitis (n = 64; 80%), especially GCA (n = 54; 67.5%). Other conditions included the presence of rheumatic diseases (n = 4; 3.2%), tumors (n = 9; 7.2%) and infections (n = 3; 2.4%). LVV-GCA patients with predominant extracranial GCA phenotype were younger (mean ± SD: 68.07 ± 9.91 vs. 75.46 ± 7.64 years; p = 0.017) and had a longer delay to the diagnosis (median [interquartile range] 12 [4-18] vs. 4 [3-8]; p = 0.006), but had polymyalgia rheumatica symptoms more frequently than those with predominantly cranial GCA phenotype (46.3% vs. 15.4%, p = 0.057). When FDG uptake was compared according to the two different disease patterns, no statistically significant differences were observed. However, patients with extracranial LVV-GCA showed a non-significantly higher frequency of vasculitic involvement of lower-extremity arteries. 
Conclusions: Regardless of the predominant phenotype, LVV identified by PET-CT is more commonly due to GCA in the Spanish population. In these GCA patients, younger age, PMR, and a higher frequency of lower-extremity artery vasculitis suggest the presence of LVV},
organization = {Funding for this study wasprovided by the Instituto de Salud Carlos III (Spain) through grant FIS PI22/01263 (PI: Dr. Miguel A. González-Gay) and the Spanish Red de Investigación RICORS RD21/0002/0025 (PI: Miguel A. González-Gay).},
publisher = {MDPI},
publisher = {Journal of Clinical Medicine, 2023, 12(19), 6164},
title = {Positron emission computed tomography spectrum of large vessel vasculitis in a tertiary center: differences in 18F-fluorodeoxyglucose uptake between large vessel vasculitis with predominant cranial and extracranial giant cell arteritis phenotypes},
author = {Heras-Recuero, Elena and Landaeta-Kancev, Laura Cristina and Martínez de Bourio-Allona, Marta and Torres-Rosello, Arantxa and Blázquez-Sánchez, Teresa and Ferraz-Amaro, Iván and Castañeda, Santos and Martínez-López, Juan Antonio and Martínez-Dhier, Luis and Largo, Raquel and González-Gay Mantecón, Miguel Ángel},
}