@article{10902/31699,
year = {2023},
url = {https://hdl.handle.net/10902/31699},
abstract = {Background: Preliminary evidence suggests that inherited hypercoagulable disorders can lead to an increased risk of significant liver fibrosis. Objective: We aimed to investigate the prevalence of significant fibrosis in patients with inherited thrombophilia, assessed by using liver stiffness (LS), and to compare this prevalence to that found in a large population-based cohort from the same region. Methods: This was a single-center, cross-sectional study. A complete laboratory analysis for liver disease, LS by transient elastography and an abdominal ultrasound were performed in patients with inherited thrombophilia diagnosed between May 2013-February 2017. These patients were propensity score matched (ratio 1:4) with a population-based cohort from the same region (PREVHEP-ETHON study; NCT02749864; N = 5988). Results: Of 241 patients with inherited thrombophilia, eight patients (3.3%) had significant fibrosis (LS ≥8kPa). All of them had risk factors for liver disease and met diagnostic criteria for different liver diseases. After matching 221 patients with thrombophilia with 884 patients of the PREVHEP-ETHON cohort, the prevalence of significant fibrosis was similar between both cohorts (1.8% vs. 3.6%, p = 0.488). Multivariate analysis showed that age and liver disease risk factors, but not belonging to the thrombophilia cohort, were associated with the presence of significant fibrosis. The magnitude of the increased risk of significant fibrosis in patients with risk factors for liver disease was also similar in both cohorts. Conclusions: Our findings do not provide evidence supporting an association between inherited thrombophilia and an increased risk of significant liver fibrosis, independent of the presence of liver-related causes of fibrosis.},
organization = {Asociacion Española para el estudio del
Hígado, Grant/Award Number: Beca Juan
Cordoba; Instituto de Salud Carlos III, Grant/
Award Number: PI20/01258},
publisher = {Wiley-Blackwell},
publisher = {United European Gastroenterology Journal, 2023, 11, 1010-1020},
title = {No evidence of association between inherited thrombophilia and increased risk of liver fibrosis},
author = {Ezcurra, Iranzu and Puente Sánchez, Ángela María and Cuadrado Lavín, Antonio and Tamayo, Ibai and Iruzubieta Coz, Paula and Arias Loste, María Teresa and González Sánchez, Francisco José and Pellón Daben, Raúl and Sánchez Bernal, Sara and Crespo del Pozo, Juan and Acebo García, María Mercedes and López Hoyos, Marcos and Pérez Iglesias, Rocío and Cuesta, Amalia and Antón, Ángela and Echevarría, Víctor and Fábrega García, Emilio and Crespo García, Javier and Fortea Ormaechea, José Ignacio},
}