@article{10902/31659,
year = {2021},
url = {https://hdl.handle.net/10902/31659},
abstract = {Background Neuroanatomical abnormalities in first-episode psychosis (FEP) tend to be subtle and widespread. The vast majority of previous studies have used small samples, and therefore may have been underpowered. In addition, most studies have examined participants at a single research site, and therefore the results may be specific to the local sample investigated. Consequently, the findings reported in the existing literature are highly heterogeneous. This study aimed to overcome these issues by testing for neuroanatomical abnormalities in individuals with FEP that are expressed consistently across several independent samples. Methods Structural Magnetic Resonance Imaging data were acquired from a total of 572 FEP and 502 age and gender comparable healthy controls at five sites. Voxel-based morphometry was used to investigate differences in grey matter volume (GMV) between the two groups. Statistical inferences were made at p < 0.05 after family-wise error correction for multiple comparisons. Results FEP showed a widespread pattern of decreased GMV in fronto-temporal, insular and occipital regions bilaterally; these decreases were not dependent on anti-psychotic medication. The region with the most pronounced decrease-gyrus rectus-was negatively correlated with the severity of positive and negative symptoms. Conclusions This study identified a consistent pattern of fronto-temporal, insular and occipital abnormalities in five independent FEP samples; furthermore, the extent of these alterations is dependent on the severity of symptoms and duration of illness. This provides evidence for reliable neuroanatomical alternations in FEP, expressed above and beyond site-related differences in anti-psychotic medication, scanning parameters and recruitment criteria.},
organization = {This study was supported by the European Commission (PSYSCAN – Translating neuroimaging findings from research into clinical practice) (P.M., grant number 603196); International Cooperation and Exchange of the National Natural Science Foundation of China (Q.G. and A.M., grant numbers 81220108013, 8122010801, 81621003, 81761128023 and 81227002); Wellcome Trusts Innovator Award (A.M., grant number 208519/
Z/17/Z) Italian Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR) (C.R, grant number art.1, commi 314-337 legge 232/2016) and the Foundation for Science and Technology (FCT) (S.V., grant number SFRH/BD/
103907/2014).},
publisher = {Cambridge University Press},
publisher = {Psychological Medicine, 2021, 51(2), 340-350},
title = {Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis},
author = {Vieira, Sandra and Gong, Qiyong and Scarpazza, Cristina and Lui, Su and Huang, Xiaoqi and Crespo Facorro, Benedicto and Tordesillas Gutiérrez, Diana and Ortiz-García de la Foz, Víctor and Setién Suero, María Esther and Scheepers, Floor and Haren, Neeltje E. M. van and Kahn, René and Reis Marques, Tiago and Ciufolini, Simone and Di Forti, Marta and Murray, Robin M. and David, Anthony and Dazzan, Paola and McGuire, Philip and Mechelli, Andrea},
}