@article{10902/31403,
year = {2012},
url = {https://hdl.handle.net/10902/31403},
abstract = {Background: Initial reports suggested that novel A(H1N1) influenza virus (2009 A[H1N1]v) infection was significantly more severe in pregnant than in non-pregnant women. In Spain, antiviral therapy was recommended for pregnant women from the beginning of the 2009 pandemic.
Methods: The prospective cohort study included consecutive pregnant and non-pregnant women of reproductive age with a proven diagnosis of 2009 A(H1N1)v admitted to any of the 13 participating Spanish hospitals between 12 June and 10 November 2009.
Results: In total, 98 pregnant and 112 non-pregnant women with proven 2009 A(H1N1)v hospitalized during the study period were included. Influenza was more severe among non-pregnant patients than pregnant patients with respect to outcomes of both intensive care unit admission (18% versus 2%; P<0.001) and death (5 versus 0; P=0.06). Pregnant women had fewer associated comorbid conditions other than pregnancy (18% versus 44%; P<0.001); they were also admitted earlier than non-pregnant women (median days since onset of symptoms: 2 versus 3; P<0.001) and a higher percentage received early antiviral therapy (41% versus 28%; P=0.03). Neither a multivariate nor a matched cohort analysis found pregnancy to be associated with greater severity than that associated with hospitalized, seriously ill non-pregnant women.
Conclusions: 2009 A(H1N1)v influenza was not associated with worse outcomes in hospitalized pregnant women compared with non-pregnant ones of reproductive age in a context of early diagnosis and antiviral therapy.},
organization = {This work was funded by Ministerio de Ciencia e Innovación, Instituto Carlos III, cofinanced by European Development Regional Fund "A way to achieve Europe" ERDF, Spanish Network for the Research in Infectious Diseases (REIPI RD06/0008).},
publisher = {SAGE},
publisher = {Antiviral Therapy, 2012, 17(4), 719-728},
title = {Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy.},
author = {Paño-Pardo, José Ramón and Rodríguez-Baño, Jesús and Martínez-Sánchez, Nuria and Viasus, Diego and Fariñas Álvarez, María del Carmen and Leyes, María and López-Medrano, Francisco and Pachón, Jerónimo and Torre-Cisneros, Julián and Oteo, José Antonio and Pumarola, Tomás and García-Gasalla, Mercedes and Ortega, Lucía and Segura, Ferrán and Carratalá, Jordi},
}