@article{10902/31275,
year = {2023},
url = {https://hdl.handle.net/10902/31275},
abstract = {The study of mild cognitive impairment (MCI) is critical to understand the underlying processes of cognitive decline in Parkinson's disease (PD). Functional connectivity (FC) disruptions in PD-MCI patients have been observed in several networks. However, the functional and cognitive changes associated with the disruptions observed in these networks are still unclear. Using a data-driven methodology based on independent component analysis, we examined differences in FC RSNs among PD-MCI, PD cognitively normal patients (PD-CN) and healthy controls (HC) and studied their associations with cognitive and motor variables. A significant difference was found between PD-MCI vs PD-CN and HC in a FC-trait comprising sensorimotor (SMN), dorsal attention (DAN), ventral attention (VAN) and frontoparietal (FPN) networks. This FC-trait was associated with working memory, memory and the UPDRS motor scale. SMN involvement in verbal memory recall may be related with the FC-trait correlation with memory deficits. Meanwhile, working memory impairment may be reflected in the DAN, VAN and FPN interconnectivity disruptions with the SMN. Furthermore, interactions between the SMN and the DAN, VAN and FPN network reflect the intertwined decline of motor and cognitive abilities in PD-MCI. Our findings suggest that the memory impairments observed in PD-MCI are associated with reduced FC within the SMN and between SMN and attention networks.},
organization = {This work was supported by Basque Government health and consume department. Ref. 2011111074; Basque Government. Saiotek 2012. Reference: S- PE12BN012., the Basque Government Predoctoral Fellowship [PRE_2014_1_358]; research award from Fundación Jesús de Gangoiti Barrera; Basque Government predoctoral fellowship [PRE_2019_1_0085]; Spanish Ministry of Science and Innovation [PID2021-123574NB-I00]; Basque Government [PIBA-2021-1-0003]; “la Caixa” Banking Foundation [LCF/PR/HR19/52160002PID2019105520GB-100]; Ramon y Cajal Fellowship [RYC-2017-21845]; Spanish Ministry of Economy and Competitiveness [PID2019-105520GB-100]; Maria C. Rodriguez-Oroz received financial support for her research from the following national and local government bodies in Spain: Institute of Health Carlos III, Basque Country Government, Diputación Foral Guipuzcoa. BCBL acknowledges funding from the Basque Government through the BERC 2022-2025 program and by the Spanish State Research Agency through BCBL Severo Ochoa excellence accreditation CEX2020-001010-S.},
publisher = {Nature Publishing Group},
publisher = {Scientific Reports, 2023, 13, 20162},
title = {Interactions between functional networks in Parkinson's disease mild cognitive impairment},
author = {Delgado Alvarado, Manuel and Ferrer-Gallardo, Vicente J. and Paz-Alonso, Pedro M. and Caballero-Gaudes, César and Rodríguez-Oroz, María C.},
}