@article{10902/31169,
year = {2023},
url = {https://hdl.handle.net/10902/31169},
abstract = {Introduction: The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.

Methods: In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models.

Results: Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ≥30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking ≥10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk.

Conclusions: Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.},
organization = {This work was supported by the ‘Acción Transversal del Cáncer'. It was approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, and by the Catalan Government DURSI (grant 2009SGR1489).},
publisher = {BioMed Central},
publisher = {Tobacco Induced Diseases, 2023, 22, 4},
title = {Smoking history and breast cancer risk by pathological subtype: MCC-Spain study},
author = {Peñalver-Argüeso, Belén and García-Esquinas, Esther and Castelló, Adela and Fernández de Larrea-Baz, Nerea and Castaño-Vinyals, Gemma and Amiano, Pilar and Fernández-Villa, Tania and Guevara, Marcela and Fernández-Tardón, Guillermo and Alguacil, Juan and Obón-Santacana, Mireia and Gómez Acebo, Inés and Pinto-Carbó, Marina and Marcos-Gragera, Rafael and Aragonés, Nuria and Aizpurua, Amaia and Martín-Sánchez, Vicente and Ardanaz, Eva and Dierssen Sotos, Trinidad and Jiménez-Moleón, José Juan},
}