@article{10902/30981,
year = {2023},
url = {https://hdl.handle.net/10902/30981},
abstract = {Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.},
organization = {Funding: This work has been supported by the project “Heteroatom-tagged proteomics and metabolomics to study lung cancer. Influence of gut microbiota” (Ref.: PY20_00366) (Project of Excellence, Regional Ministry of Economy, Knowledge, Business and University, Andalusia, Spain). The authors are also grateful for grants 651/2018 and 115/2020 from the Spanish Society of Pneumology and Surgery (SEPAR) and grant 08/2018 from the Association of Pneumology and Thoracic Surgery (Neumosur), which were used to facilitate recruitment at the hospitals and biobank registration. The authors also thank Instituto de Salud Carlos III (AES16/01783) and wish to express their gratitude for the unrestricted funding from the Menarini Group and AstraZeneca.
Acknowledgments: We thank all the patients who volunteered and donated their biomaterials for the study.},
publisher = {MDPI},
publisher = {International Journal of Molecular Sciences, 2023, 24, 14250},
title = {Metallomic signatures of lung cancer and chronic obstructive pulmonary disease},
author = {Callejón-Leclic, Belén and Sánchez Espirilla, Saida and Gotera-Rivera, Carolina and Santana, Rafael and Díaz-Olivares, Isabel and Marín, José M. and Casanova Macario, Ciro and García Cosío, Borja and Fuster, Antonia and Solanes García, Ingrid and Torres, Juan P. de and Feu Collado, Nuria and Cabrera López, Carlos and Amado Diago, Carlos Antonio and Romero Plaza, Amparo and Padrón Fraysse, Luis Alejandro and Márquez Martín,  Eduardo and Marín Royo, Margarita and Balcells Vilarnau, Eva and Llunell Casanovas, Antonia},
}