@article{10902/30979,
year = {2023},
url = {https://hdl.handle.net/10902/30979},
abstract = {Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the clonal expansion of hematopoietic stem cells carrying certain genes associated with an increased risk of hematological malignancies. Our study analyzes the influence of CHIP on the risk of heart disease and cardiovascular events in a population with chronic kidney disease (CKD). A total of 128 patients were prospectively followed up for 18 months to detect major cardiovascular events (MACE). To detect the presence of silent heart disease, troponin I, NT-Pro-BNP, and coronary calcification were measured. A massive sequencing was performed to detect CHIP. A total of 24.2% of the patients presented CHIP, including that which was only pathogenic. The most frequently affected gene was TET2 (21.1%). Using multivariate logistic regression analysis, the presence of CHIP was not related to coronary calcification (OR 0.387, 95% CI 0.142-1.058, p = 0.387), nor was it related to troponin I or NT-Pro-BNP. A total of nine patients developed major cardiovascular events. Patients with CHIP did not have a higher risk of major cardiovascular events, although patients with DNMT3A did have a higher risk (HR 6.637, 95% CI 1.443-30.533, p = 0.015), independent of other variables. We did not find that CHIP was associated with a greater risk of silent heart disease or cardiovascular events, although those affected by DNMT3a, analyzed independently, were associated with a greater number of cardiovascular events.},
organization = {Funding: This research was funded by the Marqués de Valdecilla University Hospital—IDIVAL research institute with TRANSVAL 18/01, NextVal 18/09, MTVAL 18/01, and RICORS2040 (RD21/0005/0010).
Acknowledgments: We would like to thank our nursing team at the Nephrology Laboratory, Raquel Pelayo Alonso and Rosa Ana Sainz Alonso, and our research laboratory technician, María Consuelo Agüeros Blanco, for their help when collecting blood samples.},
publisher = {MDPI},
publisher = {Life, 2023,
13, 1801},
title = {Clonal hematopoiesis of indeterminate potential and cardiovascular risk in patients with chronic kidney disease without previous cardiac pathology},
author = {Kislikova, Maria and Batllé López, Ana and Freire Salinas, Javier and Parra Blanco, José Antonio and García-Berbel Molina, María Pilar and Agulera Fernández, Alejandro and Piñera Haces, Vicente Celestino and García Unzueta, María Teresa and Benito Hernández, Adalberto and Ruiz San Millán, Juan Carlos and Rodrigo Calabia, Emilio},
}