@article{10902/30887,
year = {2023},
url = {https://hdl.handle.net/10902/30887},
abstract = {Objective: Individuals with psychosis present a greater prevalence of chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). These chronic respiratory diseases are preceded by early lung function alterations; such as preserved ratio impaired spirometry (PRISm) or normal spirometry but low diffusion capacity of the lung for carbon monoxide (DLCO). However, there is no previous evidence on these lung function alterations in psychosis. The aim of this study is to evaluate the risk of having spirometry and DLCO alterations in subjects with psychosis compared with a control group.
Methods: Cross-sectional study on a cohort of 170 individuals including 96 subjects with psychosis and 74 sex-age-and smoking habit matched healthy controls. All subjects were under 60 years-old, and without COPD or asthma. Respiratory function was evaluated through spirometry. Clinical characteristics and DLCO values were recorded.
Results: Patients with psychosis showed lower spirometry results, both in terms of absolute and percentage of Forced Vital Capacity (FVC) and Forced Expiratory Volume in one second (FEV1). Absolute and percentage levels of diffusion were also lower in patients with psychosis. The percentage of individuals with DLCO<80% was higher among patients with psychosis (75% vs. 40%, p < 0.001). And the prevalence of PRISm was higher among patients with psychosis (10.4% vs. 1.4%, p < 0.001). Multivariate logistic regression analysis indicated that psychosis was an independent predictor of DLCO<80% (OR 5.67, CI95% 1.86?17.27).
Conclusion: Patients with psychosis and females had early alterations in lung function. These results suggest that early screening for lung disease should be encouraged in psychosis.},
organization = {Funding: This work was supported by the Instituto de Investigación Sanitaria Valdecilla [grant numbers PRIMVAL17/06, INT/A20/04, and INT/A21/10]; and the Instituto de Salud Carlos III [grant number INT22/00029]. These sponsors did not have any involvement in any of the following: the study design; the collection, analysis and interpretation of data; the writing of the report; or the decision to submit the article for publication.
Acknowledgements: We are highly indebted to the participants and their families for their cooperation in this study. We also wish to thank all members of the PAFIP team for their clinical work.},
publisher = {Elsevier},
publisher = {Journal of Psychosomatic Research, 2023, 176, 111554},
title = {Individuals with psychosis present a reduced lung diffusion capacity and early spirometry alterations: results from a cross-sectional study},
author = {Viejo Casas, Ana and Amado Diago, Carlos Antonio and Agüero Calvo, Juan and Gómez Revuelta, Marcos and Ruiz Núñez, Mario and Juncal Ruiz, María and Pérez Iglesias, Rocio and Fuentes Pérez, Paloma Guadalupe and Crespo Facorro, Benedicto and Vázquez Bourgon, Javier},
}