@article{10902/30615,
year = {2023},
url = {https://hdl.handle.net/10902/30615},
abstract = {Interleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology is highest between IL-17A and IL-17F, displaying certain overlapping functions. In general, IL-17A and IL-17F play important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections, and signaling mainly through activation of the nuclear factor-kappa B (NF-kB) pathway. The role of IL-17A and IL-17F has been established in chronic immune-mediated inflammatory diseases (IMIDs), such as psoriasis (PsO), psoriatic arthritis (PsA), axial spondylarthritis (axSpA), hidradenitis suppurativa (HS), inflammatory bowel disease (IBD), multiple sclerosis (MS), and asthma. CD4+ helper T cells (Th17) activated by IL-23 are well-studied sources of IL-17A and IL-17F. However, other cellular subtypes can also produce IL-17A and IL-17F, including gamma delta (gd) T cells, alpha beta (ab) T cells, type 3 innate lymphoid cells (ILC3), natural killer T cells (NKT), or mucosal associated invariant T cells (MAIT). Interestingly, the production of IL-17A and IL-17F by innate and innatelike lymphocytes can take place in an IL-23 independent manner in addition to IL-23 classical pathway. This would explain the limitations of the inhibition of IL23 in the treatment of patients with certain rheumatic immune-mediated conditions such as axSpA. Despite their coincident functions, IL-17A and IL-17F contribute independently to chronic tissue inflammation having somehow nonredundant roles. Although IL-17A has been more widely studied, both IL-17A and IL-17F are overexpressed in PsO, PsA, axSpA and HS. Therefore, dual inhibition of IL-17A and IL-17F could provide better outcomes than IL-23 or IL-17A blockade.},
organization = {Funding. The writing assistance has been sponsored by UCB Pharma. 
Acknowledgments. Authors would express gratitude to Meisys (Madrid, Spain) for writing assistance.},
publisher = {Frontiers Research Foundation},
publisher = {Frontiers in Immunology, 2023, 14, 1191782},
title = {The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases},
author = {Navarro-Compán, Victoria and Puig, Lulis and Vidal, Silvia and Ramírez, Julio and Llamas-Velasco, Mar and Fernández-Carballido, Cristina and Almodóvar, Raquel and Pinto, José Antonio and Galínez-Aguirregoikoa, Eva and Zarco, Pedro and Joven, Beatriz and Gratacós, Jordi and Juanola, Xavier and Blanco Alonso, Ricardo and Arias-Santiago, Salvador and Sanz Sanz, Jesús and Queiro, Rubén and Cañete, Juand D.},
}