@article{10902/30591,
year = {2016},
url = {https://hdl.handle.net/10902/30591},
abstract = {Cardiovascular disease (CV) is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). This is the result of an accelerated atherosclerotic process. Adequate CV risk stratification has special relevance in RA to identify patients at risk of CV disease. However, current CV risk screening and management strategies underestimate the actual CV risk in RA. Consequently, the search for additional tools that may help to identify those patients at high CV risk has become a key objective in the last years. In this regard, non-invasive surrogates, such as carotid ultrasonography, have been found to be excellent predictors of future CV events. In addition, several studies have revealed the relevance of a genetic component in the development of CV disease in RA patients. Besides an association with HLA-DRB1* shared epitope alleles other gene polymorphisms located inside and outside the HLA seem to influence the risk of cardiovascular disease in RA. Moreover, serum levels of some metabolic syndrome-related biomarkers, adipokines such as adiponectin and biomarkers of endothelial cell activation and inflammation such as Osteoprotegerin and Asymmetric dimethylarginine have recently been found useful for the prediction of CV disease in these patients. An update of the current knowledge on these potential markers, especially focused on new genetic and serological biomarkers is shown in this review},
organization = {This work was supported by European Union FEDER funds and “Fondo de Investigación Sanitaria” (grants PI06/0024,PS09/00748,PI12/00060 and PI15/00525)from ‘Instituto de Salud Carlos III’ (ISCIII,Health Ministry,Spain).It was also partially supported by RETICS Programs RD12/ 0009(RIER) from ‘Instituto de Salud Carlos III’ (ISCIII,Health Ministry, Spain),and in part by 
grants from the European IMIBT Cure Program. We wish to specially thank Mercedes García-Bermudez,Begoña Ubilla, Verónica Mijares,Patricia Fuentevilla Rodríguez,Virginia Portilla González and all the clinicians from Spanish National Health Care system that have been involved in our studies.},
publisher = {Elsevier},
publisher = {Autoimmunity Reviews
, 2016, 15, 1013-1030},
title = {Cardiovascular risk assessment in patients with rheumatoid arthritis: the relevance of clinical, genetic and serological markers},
author = {López Mejías, Raquel and Castañeda, Santos and González Juanatey, Carlos and Corrales, Alfonso and Ferraz Amaro, Iván and Genre, Fernanda and Remuzgo Martínez, Sara and Rodríguez Rodríguez, Luis and Blanco Alonso, Ricardo and Llorca Díaz, Francisco Javier and Martín, Javier and González-Gay Mantecón, Miguel Ángel},
}