@misc{10902/30555,
year = {2023},
month = {5},
url = {https://hdl.handle.net/10902/30555},
abstract = {Estrogens play important modulatory roles in multiple complex physiological and 
pathophysiological processes. They perform their roles mainly by interacting with 
estrogen receptors (ERs) which are ligand-dependent transcription factors that regulate 
gene transcription through different pathways, thereby facilitating the normal biological 
functions of estrogens. 
However, abnormal ER signaling can result in multiple disorders, including 
gynecological disorders and various types of cancer, such as breast cancer, where they 
play a fundamental role in initiation, progression and metastasis, especially in hormone 
receptor-positive or luminal breast cancer. Therefore, targeting ERs with endocrine 
therapy, alone or in combination with other targeted agents, represents the primary 
approach for treating this type of breast cancer. In addition, quantification of estrogen 
receptors is usually used as a predictor of breast cancer prognosis. 
The aim of this work is to provide an overview of different aspects of estrogen 
receptors ranging from their types, isoforms, structures, signaling pathways, 
pathological roles in breast cancer and therapeutic strategies to overcome unleashed 
endocrine resistance.},
title = {El receptor de estrógenos en el cáncer de mama},
author = {López Bienert, Paula},
}