@article{10902/30207,
year = {2023},
url = {https://hdl.handle.net/10902/30207},
abstract = {In this observational and multicenter study, that included all patients who underwent a
heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence,
management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients
with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases
(11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed,
mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC
increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds
to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for ageat-
diagnosis groups were significantly greater than those estimated for the general
Spanish population. Curative surgery, performed for 62 of 74 operable tumors,
increased the probability of patient survival since a diagnosis of CRC, from 31.6% to
75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with
inoperable tumors. Our results suggest that the incidence of CRC among HT patients is
greater than in the general population, increasing with age at HT},
organization = {This work was co-financed with FEDER funds from CIBERCV, Instituto de Salud Carlos III, and from funds from the University of A Coruña.},
publisher = {Blackwell Publishing Ltd},
publisher = {Transplant international : official journal of the European Society for Organ Transplantation, 2023, 36, 11042},
title = {Incidence and prognosis of colorectal cancer after heart transplantation: data from the spanish post-heart transplant tumor registry},
author = {Sagastagoitia-Fornie, Marta and Morán-Fernández, Laura and Blázquez-Bermejo, Zorba and Díaz-Molina, Beatriz and Gómez-Bueno, Manuel and Almenar-Bonet, Luis and López-Granados, Amador and González Vílchez, Francisco Jesús and Mirabet-Pérez, Sonia and García-Romero, Elena and Sobrino-Márquez, Jose M. and Rábago Juan-Aracil, Gregorio and Castel-Lavilla, Maria Angels and Blasco-Peiro, Teresa and Garrido-Bravo, Iris and Fuente-Galán, Luis de la and Muñiz, Javier and Crespo-Leiro, María G.},
}