@article{10902/30194,
year = {2023},
url = {https://hdl.handle.net/10902/30194},
abstract = {Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88?0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association},
publisher = {MPDI},
publisher = {Nutrients, 2023, 15(8), 1877},
title = {Yoghurt intake and gastric cancer: a pooled analysis of 16 studies of the StoP Consortium},
author = {Collatuzzo, Giulia and Negri, Eva and Pelucchi, Claudio and Bonzi, Rossella and Turati, Federica and Rabkin, Charles S. and Liao, Linda M. and Sinha, Rashmi and Palli, Domenico and Ferraroni, Monica and López-Carrillo, Lizbeth and Lunet, Nuno and Morais, Samantha and Albanes, Demetrius and Weinstein, Stephanie J. and Parisi, Dominick and Zaridze, David and Maximovitch, Dmitry and Dierssen Sotos, Trinidad and Jiménez-Moleón, José Juan},
}