@article{10902/29833,
year = {2022},
url = {https://hdl.handle.net/10902/29833},
abstract = {Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and
neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.},
publisher = {Nature Research},
publisher = {Nature Neuroscience, 2022, 25, 421-432},
title = {Genetic variants associated with longitudinal changes in brain structure across the lifespan},
author = {Brouwer, Rachel M. and Klein, Marieke and Grasby, Katrina L. and Schnack, Hugo G. and Jahanshad, Neda and Teeuw, Jalmar and Thomopoulos, Sophia I. and Sprooten, Emma and Franz, Carol E. and Gogtay, Nitin and Kremen, William S. and Panizzon, Matthew S. and Olde Loohuis, Loes M. and Whelan, Christopher D. and Aghajani, Moji and Alloza, Clara and Alnæs, Dag and Vázquez Bourgon, Javier and Ayesa Arriola, Rosa and Artiges, Eric},
}