@article{10902/29153,
year = {2022},
url = {https://hdl.handle.net/10902/29153},
abstract = {Introduction: Family studies provide a suitable approach to analyzing candidate endophenotypes of schizophrenia, including cognitive features. Objective: To characterize different neurocognitive functions in a group of patients with first episode of psychosis (FEP), their first-degree relatives (parents and siblings), and healthy controls (HC), in order to identify potential endophenotypes for schizophrenia spectrum disorders (SSD). Methods: Participants were assessed in the context of a national project in Spain called PAFIP-FAMILIAS. They completed the same neuropsychological battery, which included tests of verbal memory, visual memory, processing speed, working memory, executive functions, motor dexterity, attention, and theory of mind. Group comparisons were performed using one-way ANOVA, followed by tests of multiple comparisons when appropriate. Results: One hundred thirty-three FEP patients were included, as well as 244 of their first-degree relatives (146 parents and 98 siblings) and 202 HC. In general, relatives showed an intermediate performance between the HC and the FEP patients in all neurocognitive domains. However, the domains of executive functions and attention stood out, as relatives (especially parents) showed similar performance to FEP patients. This was replicated when selecting patients subsequently diagnosed with schizophrenia and their relatives. Conclusion: These findings suggest that executive and attention dysfunctions might have a family aggregation and could be relevant cognitive endophenotypes for psychotic disorders. The study shows the potential of exploring intra-family neuropsychological performance supporting neurobiological and genetic research in SSD.},
organization = {Funding information: Instituto de Salud Carlos III; Fundación Marqués de Valdecilla; Universidad de Cantabria
Acknowledgments: The authors wish to thank the PAFIP-FAMILIAS research team, and especially all the patients and their relatives who participated in the study. The PAFIP-FAMILIAS project received funding from the Carlos III Health Institute (FIS PI17/00221). Additionally, this work was supported by a Miguel Servet contract from the Carlos III Health Institute (Dr. Rosa Ayesa-Arriola) (CP18/00003), and a predoctoral contract (Nancy Murillo-Garcia) from the Valdecilla Biomedical Research Institute and the University of Cantabria (BOC49, REF. IDI-13).},
publisher = {John Wiley & Sons},
publisher = {Acta psychiatrica Scandinavica 2022; 145: 384-396},
title = {A family study on first episode of psychosis patients: exploring neuropsychological performance as an endophenotype},
author = {Murillo García, Nancy and Díaz-Pons, Alexandre and Fernández Cacho, Luis Manuel and Miguel-Corredera, Margarita and Martínez del Barrio, María Elena and Ortiz-García de la Foz, Víctor and Neergaard, Karl and Ayesa Arriola, Rosa},
}