@article{10902/29107,
year = {2023},
url = {https://hdl.handle.net/10902/29107},
abstract = {Objective: This study aimed to analyse whether intelligence quotient (IQ) improves, declines, or remains stable
over 10 years among FEP patients and healthy subjects.
Methods: A group of FEP patients enrolled in a Program of First Episode Psychosis in Spain called PAFIP, and a sample of Healthy Controls (HC) completed the same neuropsychological battery at baseline and approximately 10 years later, which included the WAIS vocabulary subtest to estimate premorbid IQ and 10-year IQ. Cluster analysis was performed separately in the patient group and the HC group to determine their profiles of intellectual change.
Results: One hundred and thirty-seven FEP patients were grouped into five clusters: "Improved low IQ" (9.49 % of patients), "Improved average IQ" (14.6 %), "Preserved low IQ" (17.52 %), "Preserved average IQ" (43.06 %), and "Preserved high IQ" (15.33 %). Ninety HC were grouped into three clusters: "Preserved low IQ" (32.22 % of the HC), "Preserved average IQ" (44.44 %), and "Preserved high IQ" (23.33 %). The first two clusters of FEP patients, characterized by a low IQ, earlier age at illness onset, and lower educational attainment, showed a substantial cognitive improvement. The remaining clusters demonstrated cognitive stability.
Conclusions: The FEP patients showed intellectual improvement or stability, but no decline post-onset of psychosis. However, their profiles of intellectual change are more heterogeneous than that of HC over 10 years. Particularly, there is a subgroup of FEP patients with a significant potential for long-term cognitive enhancement},
organization = {Funding: This work was supported by a Miguel Servet contract (Dr. Rosa Ayesa-Arriola) from the Carlos III Health Institute (CP18/00003); a
“Juan de la Cierva-Formación” contract (Dr. Esther Setién-Suero) from the Spanish Ministry of Science and Innovation (FJC2019-042390-I/AEI/10.13039/501100011033); and a predoctoral contract (Nancy Murillo-Garcia) from the Valdecilla Biomedical Research Institute and the University of Cantabria (BOC49, REF. IDI-13).
Acknowledgements: We acknowledge the collaboration of all members of the PAFIP team and thank the patients and their families for their participation in the study},
publisher = {Elsevier},
publisher = {Schizophrenia Research 254 (2023) 163-172},
title = {Intelligence quotient changes over 10 years: Diversity of cognitive profiles in first episode of psychosis and healthy controls},
author = {Ortíz-García de la Foz, Víctor and Miguel-Corredera, Margarita and Vázquez Bourgon, Javier and Setién-Suero, Esther and Neergaard, Karl and Moya-Higueras, Jorge and Crespo-Facorro, Benedicto and Ayesa-Arriola, Rosa and Murillo García, Nancy},
}