@article{10902/27928,
year = {2022},
url = {https://hdl.handle.net/10902/27928},
abstract = {Background: Despite medicinal advances, cancer is still a big problem requiring better diagnostic and treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were developed for these unmet needs. Methods: This study fabricated novel trifunctional MNPs of Fe3O4@PLA-PEG for drug release, MRI and magnetic fluid hyperthermia. Result: The MNPs provided a significant loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g and significantly increased transverse relaxivity (r2 = 364.75 mM-1 s-1). The in vivo study confirmed that the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could effectively reduce the tumor size in mice bearing sarcoma 180. Conclusion: The nanocarrier has potential for drug release, cancer treatment monitoring and therapy.},
organization = {The authors are grateful for the financial support by AOARD under award FA2386-17-1-4042. The Spanish government is acknowledged for the “Nanotechnology in translational hyperthermia (HIPERNANO)” research network (RED2018102626-T) and for funding under the project number MAT2017-83631-C3. NTK Thanh thanks EPSRC (EP/M015157/1). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.},
publisher = {Future Medicine Ltd.},
publisher = {Nanomedicine, 2022, 17(22), 1677-1693},
title = {Multifunctional nanocarriers of Fe3O4@PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery},
author = {Thong, Phan Quoc and Thu Huong, Le Thi and Tu, Nguyen Dac and My Nhung, Hoang Thi and Khanh, Lam and Manh, Do Hung and Nam, Pham Hong and Phuc, Nguyen Xuan and Alonso Masa, Javier and Qiao, Ju and Sridhar, Srinivas and Thu, Ha Phuong and Phan, Manh Huong and Kim Thanh, Nguyen Thi},
}