@article{10902/27779,
year = {2023},
url = {https://hdl.handle.net/10902/27779},
abstract = {Background: There is a need for identifying risk factors for hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission.

Objective: To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort.

Methods: PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit.

Results: Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065-5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319-6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757-8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124-4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080-8.322; p = 0.035) was an independent predictor of AH.

Conclusion: Falls is an independent predictor of AH in PD patients.},
publisher = {IOS Press},
publisher = {Journal of Parkinson's disease, 2023, 13(1), 105-124},
title = {Falls predict acute hospitalization in Parkinson's disease},
author = {Santos García, Diego and de Deus Fonticoba, Teresa and Cores, Carlos and Suárez Castro, Ester and Hernández Vara, Jorge and Jesús, Silvia and Mir, Pablo and Cosgaya, Marina and José Martí, Maria and Pastor, Pau and Cabo, Iria and Seijo, Manuel and Legarda, Inés and Vives, Bárbara and Caballol, Nuria and Rúiz Martínez, Javier and Croitoru, Ioana and Cubo, Esther and Miranda, Javier and Infante Ceberio, Jon},
}