@article{10902/26821,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10902/26821},
abstract = {Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008-2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p < 0.001), heart failure (42.7% vs. 52.9%, p < 0.001), surgical indication (67.7 vs. 85.1%, p < 0.001), surgery (46.3% vs. 56.3%), and in-hospital mortality (26.9% vs. 34.3%, p < 0.001). MIE was an independent predictor of in-hospital mortality (odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1-1.7, p = 0.004) but did not have an independent association with 1-year mortality (OR 1.1, 95% CI 0.9-1.4, p = 0.43). Conclusions. About one-seventh of the valvular IE patients had MIE, mainly due to mitral-aortic involvement. MIE is associated with a poor in-hospital prognosis. An early diagnosis and treatment of IE might avoid its spread to a second valve.},
organization = {Funding: This research received no external funding.
Acknowledgments: The authors of this manuscript are grateful for the collaboration of the researchers in GAMES.},
publisher = {MDPI},
publisher = {Journal of clinical medicine 2022, 11, 4736},
title = {Multivalvular Endocarditis: A Rare Condition with Poor Prognosis},
author = {Álvarez-Ceballos, Sara and González-Ramallo, Víctor and Quintana, Eduard and Muñoz, Patricia and Villa-Martínez, Sofía de la and Arnáiz de las Revillas Almajano, Francisco and Alarcón González, Arístides de and Rodríguez-Esteban, M. Ángeles and Miró, José M. and Goenaga, Miguel Ángel and Goikoetxea-Agirre. Josune and García-Vázquez, Elisa and Boix-Palop, Lucía and Martínez-Sellés, Manuel and On Behalf Of Games},
}