@article{10902/26666,
year = {2022},
url = {https://hdl.handle.net/10902/26666},
abstract = {Background: Data to support the routine use of embolic protection devices for stroke prevention during transcatheter aortic valve replacement (TAVR) are controversial. Identifying patients at high risk for peri-procedural cerebrovascular events may facilitate effective patient selection for embolic protection devices during TAVR. Aim: To generate a risk score model for stratifying TAVR patients according to peri-procedural cerebrovascular events risk. Methods and results: A total of 8779 TAVR patients from 12 centers worldwide were included. Peri-procedural cerebrovascular events were defined as an ischemic stroke or a transient ischemic attack occurring ?24 h from TAVR. The peri-procedural cerebrovascular events rate was 1.4% (n = 127), which was independently associated with 1-year mortality (hazards ratio (HR) 1.78, 95% confidence interval (CI) 1.06-2.98, p < 0.028). The TASK risk score parameters were history of stroke, use of a non-balloon expandable valve, chronic kidney disease, and peripheral vascular disease, and each parameter was assigned one point. Each one-point increment was associated with a significant increase in peri-procedural cerebrovascular events risk (OR 1.96, 95% CI 1.56-2.45, p < 0.001). The TASK score was dichotomized into very-low, low, intermediate, and high (0, 1, 2, 3-4 points, respectively). The high-risk TASK score group (OR 5.4, 95% CI 2.06-14.16, p = 0.001) was associated with a significantly higher risk of peri-procedural cerebrovascular events compared with the low TASK score group. Conclusions: The proposed novel TASK risk score may assist in the pre-procedural risk stratification of TAVR patients for peri-procedural cerebrovascular events.},
publisher = {Basel: MDPI AG},
publisher = {J Pers Med
. 2022 Jun 28;12(7):1056},
title = {Clinical Predictors for Procedural Stroke and Implications for Embolic Protection Devices during TAVR: Results from the Multicenter Transcatheter Aortic Valve Replacement In-Hospital Stroke (TASK) Study},
author = {Berkovitch, Anat and Segev, Amit and Maor, Elad and Sedaghat, Alexander and Finkelstein, Ariel and Saccocci, Matteo and Kornowski, Ran and Latib, Azeem and Torre Hernández, José María de la and Søndergaard, Lars and Mylotte, Darren and Van Royen, Niels and Zaman, Azfar G and Robert, Pierre and Sinning, Jan-Malte and Steinvil, Arie and Maisano, Francesco and Orvin, Katia and Iannopollo, Gianmarco and Lee, Dae-Hyun},
}