@article{10902/25090,
year = {2022},
url = {http://hdl.handle.net/10902/25090},
abstract = {Objectives: To identify disease-related factors associated with subclinical atherosclerosis and cardiovascular (CV) events in a large series of patients with axial spondyloarthritis (axSpA) and to identify possible differences in the effect of the potential pro-atherogenic factors between ankylosing spondylitis (AS) non-radiographic axSpA (nr-axSpA).

Methods: This is a cross-sectional observational study of the AtheSpAin cohort, a Spanish multicenter cohort to study atherosclerosis in axSpA. Subclinical atherosclerosis determined by carotid ultrasound included assessment of carotid intima-media thickness (cIMT) and plaque detection.

Results: 639 AS and 167 nr-axSpA patients were recruited. CV risk factors (CRF) and several disease-related factors showed a statistically significant association with subclinical atherosclerosis in the crude analysis. After adjustment for age, sex, and smoking (model 1), associations remained statistically significant for spinal mobility, inflammatory bowel disease, use of prednisone, and Disease-modifying antirheumatic drugs (DMARD) when assessing carotid plaques and for acute phase reactants (APR) at diagnosis, use of prednisone, DMARD, and TNF-inhibitors when measuring cIMT. In model 2, which also included classic CRF as confounding factors to identify axSpA features with a potential independent pro-atherogenic effect, the functional status was the only variable significantly associated with plaques and the use of prednisone and APR at diagnosis with cIMT. No association differences were found between both subtypes of patients. Besides, APR at diagnosis were also associated with subsequent development of CV events that had occurred in 33 patients.

Conclusion: Apart from CRF, atherosclerotic disease in AxSpA is associated with disease-related factors such as inflammatory response and disease severity, with no differences between AS and nr-axSpA.},
publisher = {Elsevier},
publisher = {Semin Arthritis Rheum
. 2022 May 28;55:152037},
title = {Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients},
author = {Rueda Gotor, Javier and Ferraz Amaro, Iván and Genre, Fernanda and González Mazón, Íñigo and Corrales, Alfonso and Calvo Río, Vanesa and Portilla, Virginia and Llorca Díaz, Francisco Javier and Expósito, Rosa and Hernández Hernández, Vanesa and Quevedo Abeledo, Juan Carlos and Rodríguez Lozano, Carlos and López Medina, Clementina and Ladehesa-Pineda, María Lourdes and Castañeda, Santos and Vicente, Esther F. and Fernández-Carballido, Cristina and Martínez-Vidal, M Paz and González-Gay Mantecón, Miguel Ángel},
}