@article{10902/24957,
year = {2021},
month = {6},
url = {http://hdl.handle.net/10902/24957},
abstract = {Acute Kidney Injury (AKI) affects up to 30% of the patients who undergo cardiac surgery (CVS) and is related to higher mortality. We aim to investigate molecular features associated with in-hospital AKI development and determine the predictive value of these features when analyzed preoperatively. This is a case-control study. From an initial cohort of 110 recruited subjects, a total of 60 patients undergoing cardiac surgery were included: 20 (33%) developed in-hospital AKI (CVS-AKI) and 40 did not (controls, CVS-C). Pre- and post-surgery samples were collected and a prospective study was carried out. A total of 312 serum samples and 258 urine samples were analyzed by nuclear magnetic resonance, mass spectrometry and ELISA. Six features predicted AKI development in pre-surgery samples: urinary kidney functional loss marker kidney injury molecule-1 (uKIM-1), 2-hydroxybutyric acid, 2-hydroxyphenylacetic acid, hippuric acid, phosphoethanolamine and spermidine. Two of them stood out as powerful predictors. Pre-surgery uKIM-1 levels were increased in CVS-AKI vs. CVS-C (AUC = 0.721, p-value = 0.0392) and associated strongly with the outcome (OR = 5.333, p-value = 0.0264). Spermidine showed higher concentration in CVS-AKI (p-value < 0.0001, AUC = 0.970) and had a strong association with the outcome (OR = 69.75, p-value < 0.0001). uKIM-1 and particularly spermidine predict in-hospital AKI associated with CVS in preoperative samples. These findings may aid in preventing postoperative AKI and improve prognosis of CVS},
organization = {Funding: This work was supported by the Instituto de Salud Carlos III co-supported by FEDER grants (PI16/01334, PI20/01103, PI17/01093, PI17/01193, IF08/3667-1, CPII15/00027, CP15/00129, PT13/0001/0013, and PRB3 [IPT17/0019-ISCIII-SGEFI/ERDF]); REDinREN (RD12/0021/0001 and RD16/0009), Fundación SENEFRO/SEN, CAM (PEJD-2019-PRE/BMD-16992 and 2018-T2/BMD-11561), and Fundación Conchita Rábago de Jiménez Díaz.
Acknowledgments: Authors acknowledge personnel from CAI-NMR in Complutense University.},
publisher = {MDPI AG},
publisher = {Antioxidants 2021, 10(6), 896},
title = {Urinary Spermidine Predicts and Associates with In-Hospital Acute Kidney Injury after Cardiac Surgery},
author = {Martin-Lorenzo, Marta and Ramos Barrón, María Angeles and Gutierrez-Garcia, Paula and Martin-Blazquez, Ariadna and Santiago-Hernandez, Aranzazu and Rodrigo Calabia, Emilio and Gómez Alamillo, Carlos and Alvarez-Llamas, Gloria},
}