@article{10902/24839,
year = {2017},
url = {http://hdl.handle.net/10902/24839},
abstract = {Purpose
Our aim was a) to compare serum Hcy levels in patients with RVO and population-based controls, and b) to evaluate whether hyperhomocysteinemia is a risk factor for RVO.

Patients and methods
Prospective case-control study of all patients diagnosed with RVO at a tertiary-care hospital, and age-and sex-matched controls taking part in a population-based prospective cohort in the same geographic area. Differences in serum Hcy between both groups were analyzed by a general linear model adjusted for age, body mass index (BMI), glomerular filtration rate (GFR), hypertension, dyslipidemia, diabetes, tobacco use and alcohol intake. Besides, we tested the relationship between hyperhomocysteinemia (> 15 µmol/L) and RVO, by a stepwise logistic regression analysis.

Results
RVO patients (n = 85) had a higher prevalence of hypertension (p = 0.002), diabetes (p = 0.008), and dyslipidemia (p = 0.04) than controls (n = 82). Adjusted median Hcy levels were higher in RVO patients (p < 0.0001). Adjusted OR for hyperhomocysteinemia were 4.4 (95% CI, 2.0-9.3; p < 0.0001) in the overall sample, and 2.6 (95% CI, 1.04-6.6; p = 0.04) and 6.1 (95% CI, 1.7-21.6; p = 0.005) for men and women, respectively.

Conclusion
Patients with RVO have higher serum Hcy levels than age- and sex-matched population-based controls. Hyperhomocysteinemia seems to be a risk factor for RVO, independent of age, BMI, GFR and classical vascular risk factors.},
publisher = {Scholarly Pages},
publisher = {J Ophthalmic Res Ocular Care 2017, 1(1):12-17},
title = {Serum Homocysteine Levels in Patients with Retinal Vein Occlusion in a Spanish Population},
author = {Hernández Hernández, José Luis and Lisa, Marta and Napal, Jose Javier and Córdoba, Ana and Olmos Martínez, José Manuel and Ruiz, Sheila and Sierra, Isabel and García Sardina, Romina},
}