@article{10902/24566,
year = {2017},
month = {8},
url = {http://hdl.handle.net/10902/24566},
abstract = {Objective: To assess the value of baseline clinical and imaging biomarkers in a cohort of asymptomatic
LRRK2 G2019S carriers for predicting conversion to Parkinson disease (PD) at 4 years.
Methods: Thirty-two asymptomatic carriers of LRRK2 G2019S mutation underwent baseline and
4-year evaluation including clinical examination (Unified Parkinson?s Disease Rating Scale, part III,
olfaction University of Pennsylvania Smell Identification Test [UPSIT]) and dopamine transporter
(DaT) SPECT (123I-ioflupane). Visual and semiquantitative analysis of images was performed. The
specific striatal binding ratio was calculated (striatal region of interest [ROI] 2 occipital ROI/
occipital ROI).
Results: Three carriers, asymptomatic at baseline, had converted to PD at 4-year evaluation.
Twenty-three participants were fully evaluated. PD converters had lower striatal DaT binding
at baseline than nonconverters (p 50.002). A baseline scan with a ratio of bilateral striatal uptake
below 1 predicted conversion to PD within the 4-year period with high sensitivity and specificity
(area under the curve 1; p 5 0.006). The slope of DaT binding decline between the 2 scans was
similar in PD converters and nonconverters. Age-adjusted UPSIT score at baseline and at 4 years
was similar in both groups.
Conclusions: Semiquantitative DaT-SPECT could be used to predict early conversion to PD in
asymptomatic carriers of the LRRK2 G2019S mutation. Rate of conversion to PD at 4 years in
this cohort aged ;64 years was 12%. The slope of DaT binding decline on DaT-SPECT imaging
seems to be similar across different stages of the premotor period},
publisher = {American Academy of Neurology},
publisher = {Neurology, 2017, 89(5), 439-444},
title = {Prospective clinical and DaT-SPECT imaging in premotor LRRK2 G2019S-associated Parkinson disease},
author = {Sierra Peña, María and Martínez Rodríguez, Mª Isabel and Sánchez-Juan, Pascual and González-
Aramburu, Isabel and Jiménez-Alonso, Mikel and Sánchez-
Rodríguez, Antonio and Berciano, José Ángel and Banzo, Ignacio and Infante Ceberio, Jon},
}