@article{10902/24434,
year = {2021},
url = {http://hdl.handle.net/10902/24434},
abstract = {The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients.},
organization = {Funding: This research was partially supported by a grant from Spanish Society of Pulmonology and Thoracic Surgery (SEPAR 474-2017). S.R.-M. was supported by funds of the RETICS Program (RD16/0012/0009) from the “Instituto de Salud Carlos III” (ISCIII), co-funded by the European Regional Development Fund. V.P.-C. was supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). B.A.-M. was recipient of a “López Albo” post-residency program funded by Servicio Cántabro de Salud. L.L.-G. was supported by funds from IDIVAL (INNVAL 20/06). O.G. was beneficiary of a grant funded by Xunta de Galicia, Consellería de Educación, Universidade e Formación Profesional and Consellería de Economía, Emprego e Industria (GAIN), GPC IN607B2019/10. R.L.-M. was a recipient of a Miguel Servet type I program fellowship from the ISCIII, co-funded by the ESF, “Investing in your future” (grant CP16/00033).},
publisher = {Biomedicines
. 2021 Apr 22;9(5):458},
title = {Role of VEGF polymorphisms in the susceptibility and severity of interstitial lung disease},
author = {Remuzgo Martínez, Sara and Genre, Fernanda and Pulito-Cueto, Verónica and Atienza Mateo, Belén  and Mora Cuesta, Víctor Manuel and Iturbe Fernández, David and Fernández Rozas, Sonia María and Lera-Gómez, Leticia and Alonso Lecue, Pilar and Ussetti, María Piedad and Laporta, Rosalía and Berastegui, Cristina and Solé, Amparo and Pérez, Virginia and Pablo Gafas, Alicia de and Gualillo, Oreste and Cifrián Martínez, José Manuel and López Mejías, Raquel and González-Gay Mantecón, Miguel Ángel},
}