@article{10902/24102,
year = {2021},
month = {11},
url = {http://hdl.handle.net/10902/24102},
abstract = {Objective: SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis.

Methods: We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil ?4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease.

Results: From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients.

Conclusion: Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage.},
organization = {Funding: The RELESSER Registry was partially funded by GlaxoSmithKline (GSK), Roche, Union Chimique Belge (UCB), Lilly and Novartis.},
publisher = {Oxford University Press},
publisher = {Rheumatology (Oxford)
. 2021 Nov 3;60(11):5329-5336},
title = {Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?},
author = {Tejera Segura, Beatriz and Altabás González, Irene and Rúa-Figueroa, Iñigo and Pérez Veiga, Natalia and Del Campo Pérez, Victor and Olivé-Marqués, Alejandro and Galindo, María and Calvo, Jaime and Ovalles-Bonilla, Juan Gabriel and Fernández-Nebro, Antonio and Menor-Almagro, Raúl and Tomero, Eva and Del Val Del Amo, Natividad and Uriarte-Itzazelaia, Esther and Martínez Taboada, Víctor Manuel and Andreu, Jose L and Boteanu, Alina and Narváez, Javier and Movasat, Atusa and Montilla, Carlos},
}