@article{10902/24081,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10902/24081},
abstract = {There is increasing evidence of the relationship between sleep and neurodegeneration, but this knowledge is not incorporated into clinical practice yet. We aimed to test whether a basic sleep parameter, as total sleep estimated by actigraphy for 1 week, was a valid predictor of CSF Alzheimer’s Disease core biomarkers (amyloid-β-42 and –40, phosphorylated-tau-181, and total-tau) in elderly individuals, considering possible confounders and effect modifiers, particularly the APOE ε4 allele. One hundred and twenty-seven cognitively unimpaired volunteers enrolled in the Valdecilla Study for Memory and Brain Aging participated in this study. Seventy percent of the participants were women with a mean age of 65.5 years. After adjustment for covariates, reduced sleep time significantly predicted higher t-tau and p-tau. This association was mainly due to the APOE ε4 carriers. Our findings suggest that total sleep time, estimated by an actigraphy watch, is an early biomarker of tau pathology and that APOE modulates this relationship. The main limitation of this study is the limited validation of the actigraphy technology used. Sleep monitoring with wearables may be a useful and inexpensive screening test to detect early neurodegenerative changes.},
organization = {This work was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigación Sanitario, PI08/0139, PI12/02288, PI16/01652, and PI20/01011), the JPND (DEMTEST PI11/03028), the CIBERNED, and the Siemens Healthineers},
publisher = {Frontiers Research Foundation},
publisher = {Frontiers in Aging Neuroscience, 2021, 13, 663446},
title = {Sleep time estimated by an actigraphy watch correlates with CSF tau in cognitively unimpaired elders: the modulatory role of APOE},
author = {López García, Sara and Lage Martínez, Carmen and Pozueta Cantudo, Ana and García Martínez, María and Kazimierczak, Marta Eryka and Fernández Rodríguez, Andrea and Bravo González, María and Reyes González, Luis Rafael and Irure Ventura, Juan and López Hoyos, Marcos and Rodríguez Rodríguez, Eloy Manuel and Sánchez-Juan, Pascual},
}