@article{10902/24020,
year = {2021},
month = {1},
url = {http://hdl.handle.net/10902/24020},
abstract = {The LRRK2 gene has rare (p.G2019S) and common risk variants for Parkinson?s disease (PD). DNM3 has
previously been reported as a genetic modifier of the age at onset in PD patients carrying the LRRK2
p.G2019S mutation. We analyzed this effect in a new cohort of LRRK2 p.G2019S heterozygotes (n ¼ 724)
and meta-analyzed our data with previously published data (n ¼ 754). VAMP4 is in close proximity to
DNM3, and was associated with PD in a recent study, so it is possible that variants in this gene may be
important. We also analyzed the effect of VAMP4 rs11578699 on LRRK2 penetrance. Our analysis of DNM3
in previously unpublished data does not show an effect on age at onset in LRRK2 p.G2019S carriers;
however, the inter-study heterogeneity may indicate ethnic or population-specific effects of DNM3. There
was no evidence for linkage disequilibrium between DNM3 and VAMP4. Analysis of sporadic patients
stratified by the risk variant LRRK2 rs10878226 indicates a possible interaction between common vari-
ation in LRRK2 and VAMP4 in disease risk},
publisher = {Elsevier},
publisher = {Neurobiology of Aging,  Volume 97, January 2021, Pages 148.e17-148.e24},
title = {Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson´s disease},
author = {Brown, Emmeline E. and Blauwendraat, Cornelis and Trinh, Joanne and Rizig, Mie and Nalls, Mike A. and Leveille, Etienne and Ruskey, Jennifer A. and Jonvik, Hallgeir and Tan, Manuela M.X. and Bandres-Ciga, Sara and Hassin-Baer, Sharon and Brockmann, Kathrin and Infante Ceberio, Jon and Tolosa, Eduardo and Ezquerra, Mario and Romdhan, Sawssan Ben and Benmahdjoub, Mustapha and Arezki, Mohamed and Mhiri, Chokri and Hardy, John},
}