@article{10902/23920,
year = {2022},
month = {5},
url = {http://hdl.handle.net/10902/23920},
abstract = {Iron nanoparticles encapsulated within graphene shells (Fe@C) were examined for cellular internalization, subcellular behavior, biocompatibility, and influence on cell viability and proliferation. Studies on human lung (adenocarcinoma human alveolar basal epithelial) and skin (epidermoid carcinoma) cells indicate Fe@C is less toxic and more biocompatible than the magnetite nanoparticles coated by an amorphous carbon (Fe3O4@C). Fe3O4@C exhibited more signs of degradation than Fe@C when exposed to murine macrophages (mouse monocyte-macrophages J774). Unlike Fe3O4@C, Fe@C has a high drug loading capacity (0.18 g/g) for ferulic acid, an active pharmaceutical ingredient found in the traditional Chinese herb Angelica sinensis and releases the drug at a constant dosing rate of 8.75 mg/g/day over 30 days. Ferulic acid released by Fe@C injected subcutaneously in diabetic BALB/c mice is effective in lowering the blood glucose level.},
organization = {This work is supported by the Horizon 2020 BIORIMA project and the Hong Kong Research Grant Council E-HKUST601/17 and Dr. B.H. Zhong is a recipient of the HKJEBN Scholarship and his stay at INA is supported by the HKUST Overseas Research Award. The team is also grateful for the funding from the Spanish Ministerio de Economia y Competitividad (MINECO) through projects MAT2013-42551, PI16/00496, PI19/00349, and DTS19/00033, co-funded by ERDF/ESF, "Investing in Your Future". The authors also thank the CSIC (through the project PIE 201960E119 and the Regional Government of Aragón (DGA) for financial support through grant E28_20R. The authors acknowledge the support and the use of the installations of the Advanced Microscopy Laboratory (LMA) and the Servicio General de Apoyo a la Investigación of the University of Zaragoza along with the Material Characterization and Preparation Facility (MCPF), the Environmental Central Facility (ENVF), and the Animal and Plant Care Facility (APCF) at the Hong Kong University of Science and Technology.},
publisher = {Elsevier},
publisher = {Chemical Engineering Journal, 2022, 435(1), 134466},
title = {Graphene-encapsulated magnetic nanoparticles for safe and steady delivery of ferulic acid in diabetic mice},
author = {Zhong, Baihua and Mateu-Roldán, Adán and López Fanarraga, Mónica and Han, Wei and Muñoz Guerra, Débora and González Gómez, Jesús Antonio and Weng, Lu Tao and Ibarra, M. Ricardo and Marquina, Clara and Yeung, King Lun},
}