@article{10902/23851,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10902/23851},
abstract = {Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.},
publisher = {Basel: MDPI AG},
publisher = {J. Pers. Med. 2021, 11(12), 1318},
title = {Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study},
author = {Rojas, Itziar de and Hernández, Isabel and Montrreal, Laura and Quintela, Inés and Calero, Miguel and Royo, Jose Luís and Huerto Vilas, Raquel and González-Pérez, Antonio and Franco-Macías, Emilio and Macías, Juan and Menéndez-González, Manuel and Frank-García, Ana and Diez-Fairen, Mónica and Lage, Carmen and García-Madrona, Sebastián and Aguilera, Nuria and García-González, Pablo and Puerta, Raquel and Sotolongo-Grau, Oscar and Rodríguez Rodríguez, Eloy Manuel},
}