@article{10902/23830,
year = {2021},
url = {http://hdl.handle.net/10902/23830},
abstract = {Multiple myeloma (MM) is a hematological malignancy of plasma cells that proliferate and accumulate within the bone marrow (BM). Work from many groups has made evident that the complex microenvironment of the BM plays a crucial role in myeloma progression and response to therapeutic agents. Within the cellular components of the BM, we will specifically focus on mesenchymal stromal cells (MSCs), which are known to interact with myeloma cells and the other components of the BM through cell to cell, soluble factors and, as more recently evidenced, through extracellular vesicles. Multiple structural and functional abnormalities have been found when characterizing MSCs derived from myeloma patients (MM-MSCs) and comparing them to those from healthy donors (HD-MSCs). Other studies have identified differences in genomic, mRNA, microRNA, histone modification, and DNA methylation profiles. We discuss these distinctive features shaping MM-MSCs and propose a model for the transition from HD-MSCs to MM-MSCs as a consequence of the interaction with myeloma cells. Finally, we review the contribution of MM-MSCs to several aspects of myeloma pathology, specifically to myeloma growth and survival, drug resistance, dissemination and homing, myeloma bone disease, and the induction of a pro-inflammatory and immunosuppressive microenvironment.},
organization = {Funding: This study was funded by the Instituto de Salud Carlos III-FIS and co-financed by FEDER (PI19/01384 and PI18/01600); by the AECC (PROYE20047GUTI); the Network Center of Regenerative Medicine and Cellular Therapy of Castilla y León; and by the Gerencia Regional de Salud, Junta de Castilla y León (GRS 2066/A/19). P.M. (Patricia Maiso) was supported by a Miguel Servet fellowship from the ISCIII-FIS (CPII19/00028) co-financed by the European Social Fund; P.M. (Pedro Mogollón) is supported by a grant from IBSAL.},
publisher = {MDPI},
publisher = {Cancers (Basel)
. 2021 May 22;13(11):2542},
title = {Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression},
author = {Maiso, Patricia and Mogollón, Pedro and Ocio San Miguel, Enrique María and Garayoa, Mercedes},
}