@article{10902/21910,
year = {2020},
url = {http://hdl.handle.net/10902/21910},
abstract = {Background: The role of vitamin D status in COVID-19 patients is a matter of debate.
Objectives: To assess serum 25-hydroxyvitamin D (25OHD) levels in hospitalized patients with COVID-19 and to analyze the possible influence of vitamin D status on disease severity.
Methods: Retrospective case-control study of 216 COVID-19 patients and 197 population-based controls. Serum 25OHD levels were measured in both groups. The association of serum 25OHD levels with COVID-19 severity (admission to the intensive care unit, requirements for mechanical ventilation, or mortality) was also evaluated.
Results: Of the 216 patients, 19 were on vitamin D supplements and were analyzed separately. In COVID-19 patients, mean ± standard deviation 25OHD levels were 13.8 ± 7.2 ng/mL, compared with 20.9 ± 7.4 ng/mL in controls (P < .0001). 25OHD values were lower in men than in women. Vitamin D deficiency was found in 82.2% of COVID-19 cases and 47.2% of population-based controls (P < .0001). 25OHD inversely correlates with serum ferritin (P = .013) and D-dimer levels (P = .027). Vitamin D-deficient COVID-19 patients had a greater prevalence of hypertension and cardiovascular diseases, raised serum ferritin and troponin levels, as well as a longer length of hospital stay than those with serum 25OHD levels ?20 ng/mL. No causal relationship was found between vitamin D deficiency and COVID-19 severity as a combined endpoint or as its separate components.
Conclusions: 25OHD levels are lower in hospitalized COVID-19 patients than in population-based controls and these patients had a higher prevalence of deficiency. We did not find any relationship between vitamin D concentrations or vitamin deficiency and the severity of the disease.},
organization = {The Camargo Cohort Study was supported by grants from the Instituto de Salud Carlos III (PI18/00762), Ministerio de Economía y Competitividad, Spain, which included FEDER funds from the EU.},
publisher = {Endocrine Society},
publisher = {J Clin Endocrinol Metab
. 2021 Mar 8;106(3):e1343-e1353.},
title = {Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection},
author = {Hernández Hernández, José Luis and Nan, Daniel and Fernández Ayala, Marta and García Unzueta, María Teresa and Hernández Hernández, Miguel Ángel and López Hoyos, Marcos and Muñoz Cacho, Pedro and Olmos Martínez, José Manuel and Gutiérrez Cuadra, Manuel and Ruiz Cubillán, Juan J. and Crespo García, Javier and Martínez Taboada, Víctor Manuel},
}