@article{10902/21317,
year = {2020},
url = {http://hdl.handle.net/10902/21317},
abstract = {The major environmental risk factor for rheumatoid arthritis (RA) is smoking, which according to a widely accepted model induces protein citrullination in the lungs, triggering the production of anticitrullinated protein antibodies (ACPA) and RA development. Nevertheless, some research findings do not fit this model. Therefore, we obtained six independent cohorts with 2253 RA patients for a detailed analysis of the association between smoking and RA autoantibodies. Our results showed a predominant association of smoking with the concurrent presence of the three antibodies: rheumatoid factor (RF), ACPA and anti-carbamylated protein antibodies (ACarPA) (3 Ab vs. 0 Ab: OR = 1.99, p = 2.5 × 10?8). Meta-analysis with previous data (4491 patients) confirmed the predominant association with the concurrent presence of the three antibodies (3 Ab vs. 0 Ab: OR = 2.00, p = 4.4 ×10?16) and revealed that smoking was exclusively associated with the presence of RF in patients with one or two antibodies (RF+ 1+2 vs. RF? 0+1+2: OR = 1.32, p = 0.0002). In contrast, no specific association with ACPA or ACarPA was found. Therefore, these results showed the need to understand how smoking favors the concordance of RA specific antibodies and RF triggering, perhaps involving smoking-induced epitope spreading and other hypothesized mechanisms.},
publisher = {Nature Publishing Group},
publisher = {Scientific Reports (2020)10:3355},
title = {A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis},
author = {Cristina Regueiro and Luis Rodriguez-Rodriguez and López Mejías, Raquel and Laura Nuño and Ana Triguero-Martinez and Eva Perez-Pampin and Alfonso Corrales and Alejandro Villalba and Yolanda Lopez-Golan and Lydia Abasolo and Sara Remuzgo-Martínez and Ana M. Ortiz and Eva Herranz and Ana Martínez-Feito and Carmen Conde and Antonio Mera-Varela and Alejandro Balsa and Isidoro Gonzalez-Alvaro and González-Gay Mantecón, Miguel Ángel and Benjamín Fernandez-Gutierrez},
}