@article{10902/21242,
year = {2020},
url = {http://hdl.handle.net/10902/21242},
abstract = {Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects’ residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders.
Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44–2.87) to 3 km (1.26; 1.00–1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (≤3 km) production of metals (2.66; 1.77–4.00), surface treatment of metals (1.48; 1.08–2.02), glass and mineral fibers (2.06; 1.39–3.07), organic chemical industry (4.80; 3.20–7.20), inorganic chemical industry (6.74; 4.38–10.36), food/beverage sector (3.34; 2.38–4.68), and surface treatment using organic solvents (6.16; 4.06–9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (≤3 km) industries releasing nonylphenol (9.19; 5.91–14.28), antimony (5.30; 3.45–8.15), naphthalene (3.11; 2.16–4.49), organotin compounds (2.64; 1.76–3.98), manganese (2.53; 1.63–3.93), dichloromethane (2.52; 1.74–3.66), and vanadium (2.49; 1.59–3.91). 
Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer.},
organization = {This study was funded by: Scientific Foundation of the Spanish Association Against Cancer (Fundación Científica de la Asociación Española Contra el Cáncer (AECC) – EVP-1178/14); “Acción Transversal del Cáncer”, approved on the Spanish Ministry Council on the 11th October 2007; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP); Spain's Health Research Fund (Fondo de Investigación Sanitaria - FIS 12/01416); Carlos III Institute of Health (ISCIII) grants, cofunded by ERDF funds–a way to build Europe– (grants PI08/0533, PI08/1359, PI08/1770, PS09/00773- Cantabria, PS09/01286-Leon, PS09/01662-Granada, PS09/01903- Valencia, PS09/02078-Huelva, PI11/00226, PI11/01403, PI11/01810, PI11/01889-FEDER, PI11/02213, PI12/00150, PI12/00265, PI12/ 00488, PI12/00715, PI12/01270, PI14/00613, PI14/01219, PI15/ 00069, PI15/00914, PI15/01032, PI17-00092); the Fundación Marqués de Valdecilla (API 10/09); the Fundación Caja de Ahorros de Asturias; the University of Oviedo; the Junta de Castilla y León (LE22A10-2); the Regional Government of the Basque Country; the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10); the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra); the Catalan Government DURSI grant 2014SGR647; the European Commission grants FOOD-CT-2006- 036224-HIWATE; the Recercaixa (2010ACUP 00310); Agency for Management of University and Research Grants (AGAUR) of the Catalan Government grant 2017SGR723; and the Spanish Association 
Against Cancer (AECC) Scientific Foundation. ISGlobal is a member of the CERCA Program, Generalitat de Catalunya.},
publisher = {Elsevier},
publisher = {Environment International 144, 2020, 106055},
title = {Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)},
author = {García-Pérez, Javier and Fernández de Larrea-Baz, Nerea and Lope, Virginia and Molina, Antonio J. and O'Callaghan-Gordo, Cristina and Alonso, María Henar and Rodríguez-Suárez, Marta María and Mirón-Pozo, Benito and Alguacil, Juan and Gómez Acebo, Inés and Ascunce, Nieves and Vanaclocha-Espi, Mercedes and Amiano, Pilar and Chirlaque, María Dolores and Simó, Vicente and Jiménez-Moleón, José J. and Tardón García, Adonina and Moreno, Víctor and Castaño-Vinyals, Gemma and Martín, Vicente},
}